Evidence map›Paper›PMID 31411667›Full record

ArticleGlycobiology2019

9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells.

Ilka A Netravali, Annaiah Cariappa, Kathleen Yates, W Nicholas Haining, Alice Bertocchi, Hugues Allard-Chamard, Ian Rosenberg, Shiv Pillai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glycobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilka A NetravaliRagon Institute of MGH, MIT and Harvard, Cambridge MA 02139 and The MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Annaiah CariappaRagon Institute of MGH, MIT and Harvard, Cambridge MA 02139 and The MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Kathleen YatesDana-Farber Cancer Institute, Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA.
W Nicholas HainingDana-Farber Cancer Institute, Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA.
Alice BertocchiRagon Institute of MGH, MIT and Harvard, Cambridge MA 02139 and The MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Hugues Allard-ChamardRagon Institute of MGH, MIT and Harvard, Cambridge MA 02139 and The MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Ian RosenbergRagon Institute of MGH, MIT and Harvard, Cambridge MA 02139 and The MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Shiv PillaiRagon Institute of MGH, MIT and Harvard, Cambridge MA 02139 and The MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4M
Studies on Peripheral B Lymphocyte DevelopmentR01AI064930 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PILLAI, SHIV SUBRAMANIAM · 2006 to 2016
$3.9M
Mutations in the SIAE Gene and Susceptibility to Autoimmune DiseasesR01AI076505 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PILLAI, SHIV SUBRAMANIAM · 2009 to 2012
$1.8M
Dermatology Research Training ProgramT32AR065969 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI PONCIANO D CRUZ, Tamia Alisha Harris-Tryon · 2014 to 2026
$1.6M
NIAID NIH HHS R01 AI064930NIAID NIH HHS R01 AI076505NIAMS NIH HHS T32 AR065969NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521
6 · The paper itself

Abstract

The origins of plasmacytoid dendritic cells (pDCs) have long been controversial and progenitors exclusively committed to this lineage have not been described. We show here that the fate of hematopoietic progenitors is determined in part by their surface levels of 9-O-acetyl sialic acid. Pro-pDCs were identified as lineage negative 9-O-acetyl sialic acid low progenitors that lack myeloid and lymphoid potential but differentiate into pre-pDCs. The latter cells are also lineage negative, 9-O-acetyl sialic acid low cells but are exclusively committed to the pDC lineage. Levels of 9-O-acetyl sialic acid provide a distinct way to define progenitors and thus facilitate the study of hematopoietic differentiation.

Indexed as

AnimalsCell DifferentiationDendritic CellsHematopoietic Stem CellsMiceMice, CongenicMice, Inbred C57BLN-Acetylneuraminic AcidN-Acetylneuraminic AcidO-acetyl sialic acid9-O-acetyl sialic acidhematopietic progenitorsplasmacytoid dendritic cells

Identifiers

PMID31411667
PMCPMC6861835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.