ArticleeLife2019
Chronically implanted Neuropixels probes enable high-yield recordings in freely moving mice.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 165 citations in OpenAlex.
- SCREWx: A Screwless, Chronic, Recoverable, and Lightweight Neuropixels fixture for freely-moving rodents.bioRxiv : the preprint server for biology · 2026Article
- Density-based longitudinal neuron tracking in high-density electrophysiological recordings.Patterns (New York, N.Y.) · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- A Framework for Compressive On-Chip Action Potential Recording.IEEE transactions on bio-medical engineering · 2026Article
- Convolutional neural network models describe the encoding subspace of local circuits in auditory cortex.Nature neuroscience · 2026Article
- Mouse white matter matters: cortical origins and spatial organization of mouse white matter tracts.Brain structure & function · 2026Article
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- How distributed is the brain-wide network that is recruited for cognition?Nature reviews. Neuroscience · 2026Review
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- Brain-wide coordination of internal signals during decision-making.bioRxiv : the preprint server for biology · 2025Article
- A modular, adaptable, and accessible implant kit for chronic electrophysiological recordings in rats.Cell reports methods · 2025Article
- Time-adaptive modulation of evidence evaluation in rat posterior parietal cortex.bioRxiv : the preprint server for biology · 2025Article
- Automatic OptoDrive for Extracellular Recordings and Optogenetic Stimulation in Freely Moving Mice.eNeuro · 2025Article
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- Opportunities and Challenges of Brain-on-a-Chip Interfaces.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- An adaptable, reusable, and light implant for chronic Neuropixels probes.bioRxiv : the preprint server for biology · 2024Article
- Development of Higher-Level Vision: A Network Perspective.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Adapting and facilitating responses in mouse somatosensory cortex are dynamic and shaped by experience.Current biology : CB · 2024Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The advent of high-yield electrophysiology using Neuropixels probes is now enabling researchers to simultaneously record hundreds of neurons with remarkably high signal to noise. However, these probes have not been well-suited to use in freely moving mice. It is critical to study neural activity in unrestricted animals for many reasons, such as leveraging ethological approaches to study neural circuits. We designed and implemented a novel device that allows Neuropixels probes to be customized for chronically implanted experiments in freely moving mice. We demonstrate the ease and utility of this approach in recording hundreds of neurons during an ethological behavior across weeks of experiments. We provide the technical drawings and procedures for other researchers to do the same. Importantly, our approach enables researchers to explant and reuse these valuable probes, a transformative step which has not been established for recordings with any type of chronically-implanted probe.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.