Evidence map›Paper›PMID 31411557›Full record

ReviewPharmacogenomics2019

Pharmacogenomic considerations for medications in the perioperative setting.

Ellie H Jhun, Jeffrey L Apfelbaum, David M Dickerson, Sajid Shahul, Randall Knoebel, Keith Danahey, Mark J Ratain, Peter H O'Donnell

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacogenomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A hybrid implementation-effectiveness randomized trial of CYP2D6-guided postoperative pain management.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Trial
  2. Review
  3. Genetic Testing forPharmacogenomics and personalized medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ellie H JhunCommittee on Clinical Pharmacology & Pharmacogenomics, University of Chicago, Chicago, IL, 60637, USA.
Jeffrey L ApfelbaumDepartment of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA.
David M DickersonDepartment of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA.
Sajid ShahulDepartment of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA.
Randall KnoebelDepartment of Pharmacy, University of Chicago Medicine, Chicago, IL 60637, USA.
Keith DanaheyCenter for Personalized Therapeutics, University of Chicago, Chicago, IL 60637, USA.
Mark J RatainCommittee on Clinical Pharmacology & Pharmacogenomics, University of Chicago, Chicago, IL, 60637, USA.
Peter H O'DonnellCommittee on Clinical Pharmacology & Pharmacogenomics, University of Chicago, Chicago, IL, 60637, USA.

Funding

CLINICAL THERAPEUTICST32GM007019 · NIGMS · UNIVERSITY OF CHICAGO · PI Peter Hugh O'Donnell, MARK J RATAIN · 1985 to 2026
$8.7M
Implementation of Point-of-Care Pharmacogenomic Decision Support in Perioperative Care - Resubmission 01R01HG009938 · NHGRI · UNIVERSITY OF CHICAGO · PI O'DONNELL, PETER HUGH · 2018 to 2022
$4.0M
NHGRI NIH HHS R01 HG009938NIGMS NIH HHS T32 GM007019
6 · The paper itself

Abstract

Several high-profile examples of adverse outcomes from medications used in the perioperative setting are well known (e.g., malignant hyperthermia, prolonged apnea, respiratory depression, inadequate analgesia), leading to an increased understanding of genetic susceptibilities underlying these risks. Pharmacogenomic information is increasingly being utilized in certain areas of medicine. Despite this, routine preoperative genetic screening to inform medication risk is not yet standard practice. In this review, we assess the current readiness of pharmacogenomic information for clinical consideration for several common perioperative medications, including description of key pharmacogenes, pharmacokinetic implications and potential clinical outcomes. The goal is to highlight medications for which emerging or considerable pharmacogenomic information exists and identify areas for future potential research.

Indexed as

Pharmacogenomic TestingDrug-Related Side Effects and Adverse ReactionsGenetic Predisposition to DiseaseGenetic TestingHumansPerioperative CarePharmacogeneticsPrecision Medicineanalgesiaanesthesiagenetic markersgenomicsgenotypingperioperativepharmacogeneticspharmacogenomicprecision medicinesurgery

Identifiers

PMID31411557
PMCPMC6949515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.