ArticleNeuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition2020
The longitudinal associations between cognition, mood and striatal dopaminergic binding in Parkinson's Disease.
Article in Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis.Psychopharmacology · 2021Pooled it
- Neuroimaging of Anxiety in Parkinson's Disease: A Systematic Review.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson's Disease Psychosis.BMJ mental health · 2025Article
- Socioenvironmental Factors are Associated With Dopamine Transporter Availability in Healthy Individuals but not in Parkinson's Disease.Journal of geriatric psychiatry and neurology · 2025Article
- Radiomics for Parkinson's disease classification using advanced texture-based biomarkers.MethodsX · 2023Article
- Impact of the Dopamine System on Long-Term Cognitive Impairment in Parkinson Disease: An Exploratory Study.Movement disorders clinical practice · 2023Article
- The impact of iron deposition on the fear circuit of the brain in patients with Parkinson's disease and anxiety.Frontiers in aging neuroscience · 2023Article
- Neural precursor cells tune striatal connectivity through the release of IGFBPL1.Nature communications · 2022Article
- Characterization of Parkinson's Disease Subtypes and Related Attributes.Frontiers in neurology · 2022Article
- Structural and Functional Alterations of Substantia Nigra and Associations With Anxiety and Depressive Symptoms Following Traumatic Brain Injury.Frontiers in neurology · 2022Article
- Semantic fluency and processing speed are reduced in non-cognitively impaired participants with Parkinson's disease.Journal of clinical and experimental neuropsychology · 2021Article
- A three-stage, deep learning, ensemble approach for prognosis in patients with Parkinson's disease.EJNMMI research · 2021Article
- Partial correlation coefficient for a study with repeated measurements.Statistics in biopharmaceutical research · 2021Article
- Correlation Coefficients for a Study with Repeated Measures.Computational and mathematical methods in medicine · 2020Article
- A Multi-Scale Computational Model of Excitotoxic Loss of Dopaminergic Cells in Parkinson's Disease.Frontiers in neuroinformatics · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Cognitive decline and mood symptoms are common in Parkinson's disease (PD). Reductions in striatal dopaminergic binding have been associated with worse cognition and mood. We investigated whether this association persists throughout the disease progression in newly diagnosed PD. Four-year data from Parkinson's Progression Markers Initiative (PPMI) were used. Groups consisted of left and right limb dominantly affected PD patients, and controls. Longitudinal relationships between cognition, mood and striatal binding ratios were assessed by repeated measures correlations. Reduced binding was associated with general cognitive decline in controls, reduced processing speed and increased mood symptoms in PD. Anxiety was associated with striatum only in left limb dominantly affected PD. Dominantly affected limb side did not impact striatum and cognition association. There are longitudinal associations between striatum, processing speed and anxiety. Dopamine transporter availability imaging may have some prognostic value for cognition and mood in PD.
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Registered trials
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