Evidence map›Paper›PMID 31411278›Full record

ArticleClinics (Sao Paulo, Brazil)2019

The use of probiotics as a supplementary therapy in the treatment of patients with asthma: a pilot study and implications.

Jonatas Christian Vieira Moura, Isabel Cristina Gomes Moura, Guilherme Rache Gaspar, Guilherme Matos Serretti Mendes, Bernardo Almeida Vial Faria, Nulma Souto Jentzsch, Maria do Carmo Friche Passos, Amanj Kurdi, Brian Godman, Alessandra Maciel Almeida

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
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  6. Article
  7. Review
  8. Frontiers in immunology · 2023
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Jonatas Christian Vieira MouraPrograma de Pos Graduacao em Ciencias da Saude, Faculdade de Ciencias Medicas de Minas Gerais, Belo Horizonte, MG, BR.ORCID 0000-0002-9853-4670
Isabel Cristina Gomes MouraPrograma de Pos Graduacao em Ciencias da Saude, Faculdade de Ciencias Medicas de Minas Gerais, Belo Horizonte, MG, BR.ORCID 0000-0002-5549-3426
Guilherme Rache GasparDepartamento de Pediatria, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BR.ORCID 0000-0003-0417-334X
Guilherme Matos Serretti MendesFaculdade de Medicina, Faculdade de Ciencias Medicas de Minas Gerais, Belo Horizonte, MG, BR.ORCID 0000-0002-5257-946X
Bernardo Almeida Vial FariaFaculdade de Medicina, Faculdade de Medicina de Barbacena, Barbacena, MG, BR.ORCID 0000-0001-6873-4375
Nulma Souto JentzschFaculdade de Medicina, Faculdade de Ciencias Medicas de Minas Gerais, Belo Horizonte, MG, BR.ORCID 0000-0002-7464-9457
Maria do Carmo Friche PassosPrograma de Pos Graduacao em Ciencias da Saude, Faculdade de Ciencias Medicas de Minas Gerais, Belo Horizonte, MG, BR.ORCID 0000-0002-5247-9477
Amanj KurdiPharmacoepidemiology and Pharmacy Practice, Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Scotland, UK.ORCID 0000-0001-5036-1988
Brian GodmanPharmacoepidemiology and Pharmacy Practice, Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Scotland, UK.ORCID 0000-0001-6539-6972
Alessandra Maciel AlmeidaPrograma de Pos Graduacao em Ciencias da Saude, Faculdade de Ciencias Medicas de Minas Gerais, Belo Horizonte, MG, BR.ORCID 0000-0003-0138-9401
Faculdade de Ciências Médicas de Minas Gerais · BRFundação Faculdade de Medicina · BRHawler Medical University · IQUniversidade Federal de Minas Gerais · BRUniversity of Strathclyde · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEvaluate the use of probiotics as an additional therapy in the treatment of children and adolescents with asthma in Belo Horizonte, MG-Brazil.

methodsA pilot longitudinal, experimental and nonrandomized study with 30 patients from six to 17 years old from Belo Horizonte. In the baseline appointment, all patients received beclomethasone, and one group also received a probiotic containing Lactobacillus reuteri (n=14). The patients were reassessed after at least 60 days with the Asthma Control Test, spirometry and self-report of the symptoms they experienced associated with asthma.

resultsA predominance of male patients (56.7%) and a mean age of 10.6 years were observed. The groups using probiotics did not differ in terms of sex, age or atopy. In the longitudinal evaluation, an increase in the Asthma Control Test scores and a reduction in the number of symptoms were observed in the probiotic group. There was an increase in the peak expiratory flow among those who used probiotics.

conclusionsThis pilot study supports the hypothesis that the administration of probiotics as a supplementary therapy for the treatment of children and adolescents with asthma improves the clinical condition of the patients. Further studies are needed to confirm the efficacy of probiotics in asthma treatment.

Indexed as

AdolescentAsthmaBrazilCase-Control StudiesChildFemaleHumansLimosilactobacillus reuteriLongitudinal StudiesMalePilot ProjectsProbioticsRespiratory Function TestsSpirometry

Identifiers

PMID31411278
PMCPMC6683305
OpenAlexW2947149639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.