ArticleJournal of applied oral science : revista FOB2019
Increased whitening efficacy and reduced cytotoxicity are achieved by the chemical activation of a highly concentrated hydrogen peroxide bleaching gel.
Article in Journal of applied oral science : revista FOB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Bleaching with biocatalysts and violet LED: a randomized clinical trial using a hybrid design with parallel-group and split-mouth approaches : Violet LED and biocatalysts in in-office whitening: a split-mouth trial.Clinical oral investigations · 2025Trial
- Effect of copaiba oil-resin on dental sensitivity control and color change after bleaching: A randomized clinical trial.Clinical oral investigations · 2025Trial
- Effect of bleaching gel volume on color change and postoperative sensitivity: a randomized clinical study.Clinical oral investigations · 2022Trial
- Article
- Evaluation of cytotoxicity and bleaching efficacy of gels with calcium polyphosphate and violet LED.Brazilian dental journal · 2026Article
- Effects of experimental in-office bleaching gels incorporated with co-doped titanium dioxide nanoparticles on dental enamel physical properties.Odontology · 2025Article
- Combined catalytic strategies applied to in-office tooth bleaching: whitening efficacy, cytotoxicity, and gene expression of human dental pulp cells in a 3D culture model.Clinical oral investigations · 2024Article
- Enzymatically Driven Mineralization of a Calcium-Polyphosphate Bleaching Gel.Bioengineering (Basel, Switzerland) · 2024Article
- Catalysis-based approaches with biopolymers and violet LED to improve in-office dental bleaching.Lasers in medical science · 2024Article
- Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research.Restorative dentistry & endodontics · 2023Article
- Evaluation of the Efficacy of Low-Particle-Size Toothpastes against Extrinsic Pigmentations: A Randomized Controlled Clinical Trial.Dentistry journal · 2023Article
- Calcium-Polyphosphate Submicroparticles (CaPP) Improvement Effect of the Experimental Bleaching Gels' Chemical and Cellular-Viability Properties.Gels (Basel, Switzerland) · 2023Article
- Effect of green tea extract antioxidant on dentin shear bond strength and resin-tag penetration depth after non-vital bleaching.F1000Research · 2023Article
- Strategy for reducing cytotoxicity and obtaining esthetic efficacy with 15 min of in-office dental bleaching.Clinical oral investigations · 2022Article
- Effects of 35% hydrogen peroxide solution containing hydrated calcium silicate on enamel surface.Clinical oral investigations · 2022Article
- Pro-inflammatory mediators expression by pulp cells following tooth whitening on restored enamel surface.Brazilian dental journalArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was designed for the chemical activation of a 35% hydrogen peroxide (H2O2) bleaching gel to increase its whitening effectiveness and reduce its toxicity. METHODOLOGY: First, the bleaching gel - associated or not with ferrous sulfate (FS), manganese chloride (MC), peroxidase (PR), or catalase (CT) - was applied (3x 15 min) to enamel/dentin discs adapted to artificial pulp chambers. Then, odontoblast-like MDPC-23 cells were exposed for 1 h to the extracts (culture medium + components released from the product), for the assessment of viability (MTT assay) and oxidative stress (H2DCFDA). Residual H2O2 and bleaching effectiveness (DE) were also evaluated. Data were analyzed with one-way ANOVA complemented with Tukey's test (n=8. p<0.05).
resultsAll chemically activated groups minimized MDPC-23 oxidative stress generation; however, significantly higher cell viability was detected for MC, PR, and CT than for plain 35% H2O2 gel. Nevertheless, FS, MC, PR, and CT reduced the amount of residual H2O2 and increased bleaching effectiveness.
conclusionChemical activation of 35% H2O2 gel with MC, PR, and CT minimized residual H2O2 and pulp cell toxicity; but PR duplicated the whitening potential of the bleaching gel after a single 45-minute session.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.