Evidence map›Paper›PMID 31411081›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2019

Design, synthesis and biological evaluation of N-substituted α-hydroxyimides and 1,2,3-oxathiazolidine-4-one-2,2-dioxides with anticonvulsant activity.

Laureano L Sabatier, Pablo H Palestro, Andrea V Enrique, Valentina Pastore, María L Sbaraglini, Pedro Martín, Luciana Gavernet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laureano L Sabatiera Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata , La Plata , Argentina.
Pablo H Palestroa Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata , La Plata , Argentina.
Andrea V Enriqueb Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), CONICET-Universidad Nacional de la Plata), Facultad de Ciencias Exactas, Universidad Nacional de La Plata , La Plata , Argentina.
Valentina Pastoreb Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), CONICET-Universidad Nacional de la Plata), Facultad de Ciencias Exactas, Universidad Nacional de La Plata , La Plata , Argentina.
María L Sbaraglinia Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata , La Plata , Argentina.
Pedro Martínb Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), CONICET-Universidad Nacional de la Plata), Facultad de Ciencias Exactas, Universidad Nacional de La Plata , La Plata , Argentina.
Luciana Gaverneta Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata , La Plata , Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this investigation, we studied a family of compounds with an oxathiazolidine-4-one-2,2-dioxide skeleton and their amide synthetic precursors as new anticonvulsant drugs. The cyclic structures were synthesized using a three-step protocol that include solvent-free reactions and microwave-assisted heating. The compounds were tested

Indexed as

Drug DesignAnimalsAnticonvulsantsCarbon-13 Magnetic Resonance SpectroscopyDose-Response Relationship, DrugHEK293 CellsHumansImidesMaleMiceNAV1.1 Voltage-Gated Sodium ChannelOxidesPatch-Clamp TechniquesProton Magnetic Resonance SpectroscopyThiazolesAnticonvulsantsImidesNAV1.1 Voltage-Gated Sodium ChannelOxidesThiazoles1,2,3-oxathiazolidine-4-one-2,2-dioxidedockingEpilepsyMES testmicrowave-assisted synthesissodium channels blockersα-hydroxyimides

Identifiers

PMID31411081
PMCPMC6713207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.