Evidence map›Paper›PMID 31411079›Full record

ArticleConnective tissue research2020

Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent.

Brianne K Connizzo, Judith M Piet, Sandra J Shefelbine, Alan J Grodzinsky

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Connective tissue research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Regulators of ECM structure enable functional adaptation to tensile loading in tendon explants.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Estrogen and Progesterone Exhibit Distinct Yet Coordinated Roles in the Regulation of Tendon Extracellular Matrix Remodeling.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Aged tendons lack adaptive response to acute compressive injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024
    Article
  14. Earlier proteoglycan turnover promotes higher efficiency matrix remodeling in MRL/MpJ tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  15. Review
  16. Distal Biceps Repairs in Females: A Large Single-Center Case Series.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Brianne K ConnizzoDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-7818-0537
Judith M PietDepartment of Bioengineering, Northeastern University, Boston, MA, USA.ORCID 0000-0001-8741-8538
Sandra J ShefelbineDepartment of Bioengineering, Northeastern University, Boston, MA, USA.ORCID 0000-0002-4011-9044
Alan J GrodzinskyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-4942-3456
Massachusetts Institute of Technology · USNortheastern University · US

Funding

Development of In Vitro Compression-Induced Rotator Cuff Injury Model: Aging and Inflammation in Tendon DegenerationK99AG063896 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CONNIZZO, BRIANNE KATHRYN · 2019 to 2020
$252k
The Role of Aging in the Progression of Tendon Degeneration Due to Compressive Mechanical Overload: A Multiscale ApproachF32AG052284 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CONNIZZO, BRIANNE KATHRYN · 2015 to 2018
$167k
NIA NIH HHS F32 AG052284NIA NIH HHS K99 AG063896
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell ProliferationGene Expression RegulationSex CharacteristicsStress, PhysiologicalAgingAnimalsFemaleHumansMaleMiceTendonsTissue Culture TechniquesagingexplantsexTendontenocyte

Identifiers

PMID31411079
PMCPMC6884684
OpenAlexW2969162917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.