ArticleJournal of biomedical optics2019
In vivo photoacoustic imaging of major blood vessels in the pancreas and liver during surgery.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Real-time photoacoustic imaging with freehand light delivery and augmented reality guidance.Photoacoustics · 2026Article
- Nanoengineered Macrophages for in vivo Three-Dimensional Photoacoustic Imaging and Immunotherapy of Acute Lung Injury.International journal of nanomedicine · 2026Article
- In Vivo Demonstration of Deep Learning-Based Photoacoustic Visual Servoing System.IEEE transactions on bio-medical engineering · 2026Article
- Motion-based dynamic light delivery to minimize laser-related thermal damage while preserving photoacoustic image quality.Journal of biomedical optics · 2025Article
- In vivo spatiotemporal characterizing diverse body transportation of optical labeled high immunity aluminium adjuvants with photoacoustic tomography.Photoacoustics · 2024Article
- Predictive model for laser-induced tissue necrosis with immunohistochemistry validation.Biophotonics discovery · 2024Article
- Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine.Journal of biomedical optics · 2023Review
- Flexible array transducer for photoacoustic-guided interventions: phantom andBiomedical optics express · 2023Article
- Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.Photoacoustics · 2023Review
- Image-guided surgery and novel intraoperative devices for enhanced visualisation in general and paediatric surgery: a review.Innovative surgical sciences · 2021Review
- Binary photoacoustic tomography for improved vasculature imaging.Journal of biomedical optics · 2021Article
- Annular Fiber Probe for Interstitial Illumination in Photoacoustic Guidance of Radiofrequency Ablation.Sensors (Basel, Switzerland) · 2021Article
- Optoacoustic Imaging in Inflammation.Biomedicines · 2021Review
- Photoacoustic-guided surgery from head to toe [Invited].Biomedical optics express · 2021Review
- Empirical assessment of laser safety for photoacoustic-guided liver surgeries.Biomedical optics express · 2021Article
- Deep-Learning-Based Cerebral Artery Semantic Segmentation in Neurosurgical Operating Microscope Vision Using Indocyanine Green Fluorescence Videoangiography.Frontiers in neurorobotics · 2021Article
- Photoacoustic Spatial Coherence Theory and Applications to Coherence-Based Image Contrast and Resolution.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Photoacoustic image improvement based on a combination of sparse coding and filtering.Journal of biomedical optics · 2020Article
- GPU implementation of photoacoustic short-lag spatial coherence imaging for improved image-guided interventions.Journal of biomedical optics · 2020Article
- Application of the generalized contrast-to-noise ratio to assess photoacoustic image quality.Biomedical optics express · 2020Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Abdominal surgeries carry considerable risk of gastrointestinal and intra-abdominal hemorrhage, which could possibly cause patient death. Photoacoustic imaging is one solution to overcome this challenge by providing visualization of major blood vessels during surgery. We investigate the feasibility of in vivo blood vessel visualization for photoacoustic-guided liver and pancreas surgeries. In vivo photoacoustic imaging of major blood vessels in these two abdominal organs was successfully achieved after a laparotomy was performed on two swine. Three-dimensional photoacoustic imaging with a robot-controlled ultrasound (US) probe and color Doppler imaging were used to confirm vessel locations. Blood vessels in the in vivo liver were visualized with energies of 20 to 40 mJ, resulting in 10 to 15 dB vessel contrast. Similarly, an energy of 36 mJ was sufficient to visualize vessels in the pancreas with up to 17.3 dB contrast. We observed that photoacoustic signals were more focused when the light source encountered a major vessel in the liver. This observation can be used to distinguish major blood vessels in the image plane from the more diffuse signals associated with smaller blood vessels in the surrounding tissue. A postsurgery histopathological analysis was performed on resected pancreatic and liver tissues to explore possible laser-related damage. Results are generally promising for photoacoustic-guided abdominal surgery when the US probe is fixed and the light source is used to interrogate the surgical workspace. These findings are additionally applicable to other procedures that may benefit from photoacoustic-guided interventional imaging of the liver and pancreas (e.g., biopsy and guidance of radiofrequency ablation lesions in the liver).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.