ArticleJournal of applied genetics2019
Development of gene-based molecular markers tagging low alkaloid pauper locus in white lupin (Lupinus albus L.).
Article in Journal of applied genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Quinolizidine Alkaloid Composition of White Lupin Landraces and Breeding Lines, and Near-Infrared Spectroscopy-Based Discrimination of Low-Alkaloid Material.Plants (Basel, Switzerland) · 2025Article
- Genetic variation and genome-enabled selection of white lupin for key seed quality traits.BMC genomics · 2025Article
- Identification of a new QTL associated to reduced quinolizidine alkaloid content in white lupin (Lupinus albus, L.) and development of ultra-low alkaloid recombinants by stacking with the pauper allele.BMC plant biology · 2025Article
- Evaluation of the Global White Lupin Collection Reveals Significant Associations Between HomologousInternational journal of molecular sciences · 2025Article
- Genomic structure of yellow lupin (Lupinus luteus): genome organization, evolution, gene family expansion, metabolites and protein synthesis.BMC genomics · 2025Article
- Recent Advances in Molecular Tools and Pre-Breeding Activities in White Lupin (Plants (Basel, Switzerland) · 2025Review
- Development and validation of PCR marker array for molecular selection towards spring, vernalization-independent and winter, vernalization-responsive ecotypes of white lupin (Lupinus albus L.).Scientific reports · 2025Article
- Genome-wide association study revealed significant SNPs for anthracnose resistance, seed alkaloids and protein content in white lupin.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- The causal mutation leading to sweetness in modern white lupin cultivars.Science advances · 2023Article
- Genetic Augmentation of Legume Crops Using Genomic Resources and Genotyping Platforms for Nutritional Food Security.Plants (Basel, Switzerland) · 2022Review
- Beyond a reference genome: pangenomes and population genomics of underutilized and orphan crops for future food and nutrition security.The New phytologist · 2022Review
- Progress of Genomics-Driven Approaches for Sustaining Underutilized Legume Crops in the Post-Genomic Era.Frontiers in genetics · 2022Review
- Genetic manipulation of anti-nutritional factors in major crops for a sustainable diet in future.Frontiers in plant science · 2022Review
- Mediterranean White Lupin Landraces as a Valuable Genetic Reserve for Breeding.Plants (Basel, Switzerland) · 2021Article
- Quantitative Control of Early Flowering in White Lupin (International journal of molecular sciences · 2021Article
- A Bitter-Sweet Story: Unraveling the Genes Involved in Quinolizidine Alkaloid Synthesis inFrontiers in plant science · 2021Review
- Development of PCR-based markers and whole-genome selection model for anthracnose resistance in white lupin (Lupinus albus L.).Journal of applied genetics · 2020Article
- The Effects of Domestication on Secondary Metabolite Composition in Legumes.Frontiers in genetics · 2020Review
- Candidate Domestication-Related Genes Revealed by Expression Quantitative Trait Loci Mapping of Narrow-Leafed Lupin (International journal of molecular sciences · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
White lupin (Lupinus albus L.) is a legume grain crop cultivated since ancient Greece and Egypt. Modern white lupin cultivars are appreciated as a source of protein with positive nutraceutical impact. However, white lupins produce anti-nutritional compounds, quinolizidine alkaloids, which provide bitter taste and have a negative influence on human health. During domestication of this species, several recessive alleles at unlinked loci controlling low alkaloid content were selected. One of these loci, pauper, was exploited worldwide providing numerous low-alkaloid cultivars. However, molecular tracking of pauper has been hampered due to the lack of diagnostic markers. In the present study, the synteny-based approach was harnessed to target pauper locus. Single-nucleotide polymorphisms flanking pauper locus on white lupin linkage map as well as candidate gene sequences elucidated from the narrow-leafed lupin (L. angustifolius L.) chromosome segment syntenic to the pauper linkage group region were transformed to PCR-based molecular markers. These markers were analyzed both in the mapping population and world germplasm collection. From fourteen markers screened, eleven were localized at a distance below 1.5 cM from this locus, including five co-segregating with pauper. The linkage of these markers was confirmed by high LOD values (up to 58.4). Validation performed in the set of 127 bitter and 23 sweet accessions evidenced high applicability of one marker, LAGI01_35805_F1_R1, for pauper locus selection, highlighted by the low ratio of false-positive scores (2.5%). LAGI01_35805 represents a homolog of L. angustifolius acyltransferase-like (LaAT) gene which might hypothetically participate in the alkaloid biosynthesis process in lupins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.