SynthesisWorld journal of pediatrics : WJP2020
Maternal exposure to antibiotics increases the risk of infant eczema before one year of life: a meta-analysis of observational studies.
Synthesis in World journal of pediatrics : WJP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Prenatal maternal antibiotic use increases the risk of childhood eczema: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Safety of anti-infective agents use during pregnancy on offspring: protocol for an umbrella review incorporating a novel three-stage data extraction strategy.Systematic reviews · 2026Article
- Association of Prenatal and Intrapartum Antibiotic Use with Risk of Childhood Atopic Dermatitis: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Association between antibiotic exposure and childhood atopic dermatitis: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Prevention of IgE-Mediated Food Allergy: Emerging Strategies Through Maternal and Neonatal Interventions.The journal of allergy and clinical immunology. In practice · 2024Review
- Prenatal and Perinatal Antibiotic Exposure and Long-Term Outcome.Pediatric gastroenterology, hepatology & nutrition · 2023Review
- Maternal exposure to antibiotics and risk of atopic dermatitis in childhood: a systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- A cohort study of intrapartum group B streptococcus prophylaxis on atopic dermatitis in 2-year-old children.BMC pediatrics · 2022Article
- Impacts of ceftriaxone exposure during pregnancy on maternal gut and placental microbiota and its influence on maternal and offspring immunity in mice.Experimental animals · 2021Article
- Delayed Gut Colonization Shapes Future Allergic Responses in a Murine Model of Atopic Dermatitis.Frontiers in immunology · 2021Article
- The Role of Environmental Exposures in Atopic Dermatitis.Current allergy and asthma reports · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are some conflicting evidences showing that maternal exposure to antibiotics may increase the risk of infant eczema. The present study aims to estimate the effect of prenatal antibiotics administration on infant eczema.
methodsAccording to the established inclusion criteria, eligible observational studies were collected by comprehensive database search. The qualities of the included studies were assessed using the Newcastle-Ottawa Scale. Effect sizes that were adjusted by multivariable models were extracted and combined. Publication bias was evaluated by visual inspection of funnel plot.
resultsA total of seven observational studies were included. The qualities of the included studies were at moderate or high level. Prenatal antibiotics use was positively associated with eczema before one year of age [odds ratio (OR) = 1.93, 95% confidence interval (CI) 1.35-2.76]. In addition, antibiotics exposure in utero was likely to be related to eczema after one year of age (OR 1.21, 95% CI 0.98-1.49). The exposure to antibiotics during third trimester was not associated with infant eczema (OR 0.97, 95% CI 0.86-1.09).
conclusionsMaternal exposure to antibiotics is associated with eczema by one-year age and may have a prolonged effect on eczema after 1-year age. The influence of timing of antibiotics exposure during pregnancy needs more studies to clarify.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.