ArticleJournal of autism and developmental disorders2019
Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder.
Article in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Steroid hormone pathways, vitamin D and autism: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2023Pooled it
- Perfluorooctanoic acid disrupts hepatic metabolism in the developing chicken embryo.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Valproate-Induced Autism and Sexual Hormone Disturbances: A Literature Review and Hypotheses.Neurochemical research · 2025Review
- A dataset of synthetic, maturation-informed magnetic resonance images of the human fetal brain.Scientific data · 2025Article
- Deep learning microstructure estimation of developing brains from diffusion MRI: A newborn and fetal study.Medical image analysis · 2024Article
- Gonadal hormones impart male-biased behavioral vulnerabilities to immune activation via microglial mitochondrial function.Brain, behavior, and immunity · 2024Article
- Sex-specific and sex-independent steroid-related biomarkers in early second trimester maternal serum associated with autism.Molecular autism · 2023Article
- Sex differences in placenta-derived markers and later autistic traits in children.Translational psychiatry · 2023Article
- Deep learning microstructure estimation of developing brains from diffusion MRI: a newborn and fetal study.bioRxiv : the preprint server for biology · 2023Article
- The genetics of autism and steroid-related traits in prenatal and postnatal life.Frontiers in endocrinology · 2023Article
- Maternal androgens and autism spectrum disorder in the MARBLES prospective cohort study.Research in autism spectrum disorders · 2022Article
- A Fetal Brain magnetic resonance Acquisition Numerical phantom (FaBiAN).Scientific reports · 2022Article
- Maternal steroid levels and the autistic traits of the mother and infant.Molecular autism · 2021Article
- Signaling Pathways and Sex Differential Processes in Autism Spectrum Disorder.Frontiers in psychiatry · 2021Review
- Associations Between Sex Hormone Levels and Autistic Traits in Infertile Patients With Polycystic Ovary Syndrome and Their Offspring.Frontiers in endocrinology · 2021Article
- The Prenatal Hormone Milieu in Autism Spectrum Disorder.Frontiers in psychiatry · 2021Review
- Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort.Molecular autism · 2020Article
- MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes.International journal of molecular sciences · 2020Review
- Prenatal sex hormones and behavioral outcomes in children.Psychoneuroendocrinology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Epidemiologic studies link increased autism spectrum disorder (ASD) risk to obstetrical conditions associated with inflammation and steroid dysregulation, referred to as prenatal metabolic syndrome (PNMS). This pilot study measured steroid-related biomarkers in early second trimester maternal serum collected during the first and second trimester evaluation of risk study. ASD case and PNMS exposure status of index offspring were determined through linkage with autism registries and birth certificate records. ASD case (N = 53) and control (N = 19) groups were enriched for PNMS exposure. Higher estradiol and lower sex hormone binding globulin (SHBG) were significantly associated with increased ASD risk. Study findings provide preliminary evidence to link greater placental estradiol activity with ASD and support future investigations of the prenatal steroid environment in ASD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.