ArticleJournal of the American Society for Mass Spectrometry2019
Reaction Acceleration in Electrospray Droplets: Size, Distance, and Surfactant Effects.
Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Molecular Framework Modification in Mass Spectrometry: Atom Exchange, Insertion, and Deletion.Journal of the American Society for Mass Spectrometry · 2026Article
- Enhancement of Esterification Reaction Rates in Solvent-Free Aerosol Droplets.Journal of the American Chemical Society · 2026Article
- Photoelectron imaging of substituted benzenes in aqueous aerosol droplets.Physical chemistry chemical physics : PCCP · 2026Article
- Microdroplet Mass Spectrometry Enables Rapid and Sensitive Measurement of Glucose Homeostasis for Elucidating Mechanism of Drug Action.Analytical chemistry · 2025Article
- Measurements and Model Predictions for the Surface Tension of Aerosol Droplets Containing Mixtures of Strong Nonionic Surfactants and Organic Solutes.Environmental science & technology · 2025Article
- Coaxial Electrospray of Nanodrug-Loaded Porous Polylactic Acid/Poly(Ethylene Oxide) Core-Shell Microparticles for Intrapulmonary Drug Delivery.Journal of biomedical materials research. Part A · 2025Article
- Humidity drives spontaneous OH oxidation of organic particles.Science advances · 2025Article
- A Source of the MysteriousACS central science · 2025Article
- Model-Measurement Comparisons for Surfactant-Containing Aerosol Droplets.ACS earth & space chemistry · 2024Article
- Reaction acceleration at the surface of a levitated droplet by vapor dosing from a partner droplet.Chemical science · 2024Article
- Surfactant Partitioning Dynamics in Freshly Generated Aerosol Droplets.Journal of the American Chemical Society · 2024Article
- Preparation of RDX/F2311/FeMaterials (Basel, Switzerland) · 2024Article
- Oxazolone mediated peptide chain extension and homochirality in aqueous microdroplets.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Surface-Area-to-Volume Ratio Determines Surface Tensions in Microscopic, Surfactant-Containing Droplets.ACS central science · 2023Article
- The role of analyte concentration in accelerated reaction rates in evaporating droplets.Chemical science · 2023Article
- Reaction nanoscopy of ion emission from sub-wavelength propanediol droplets.Nanophotonics (Berlin, Germany) · 2023Article
- Abiotic microcompartments form when neighbouring droplets fuse: an electrochemiluminescence investigation.Chemical science · 2023Article
- Gas Dynamic Virtual Nozzle Sprayer for an Introduction of Liquid Samples in Atmospheric Pressure Ionization Mass Spectrometry.Analytical chemistry · 2023Article
- Rapid Characterization of Antibodies via Automated Flow Injection Coupled with Online Microdroplet Reactions and Native-pH Mass Spectrometry.Analytical chemistry · 2023Article
- Aqueous microdroplets enable abiotic synthesis and chain extension of unique peptide isomers from free amino acids.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Phenylhydrazone formation from isatin is used to examine the effects on the reaction rate of (i) electrospray emitter distance from the mass spectrometer (MS) inlet, (ii) emitter tip diameter, and (iii) presence of surfactant. Reaction rates are characterized through measurement of conversion ratios. It is found that there is an increase in the conversion ratio as (i) the electrospray source is moved further from the inlet of the mass spectrometer, (ii) smaller sprayer diameters are used, and (iii) when surfactants are present. Each of these experimental operations is associated with an increase in reaction rate and with a decrease in average droplet sizes. The size measurements are made using super resolution microscopy from the "splash" on a collector surface produced by a fluorescent marker sprayed using conditions similar to those used for the reaction mixture. This measurement showed that droplets undergo significant evaporation as a function of distance of flight, thereby increasing their surface to volume ratios. Similarly, the effect of nanoelectrospray emitter size on conversion ratio is also found to be associated with changes in droplet size for which a 4 to 10 times increase in reaction rate is seen using tip diameters ranging from 20 μm down to 1 μm. Finally, the effects of surfactants in producing smaller droplets with corresponding large increases in reaction rate are demonstrated by splash microscopy. These findings point to reaction acceleration being strongly associated with reactions at the surfaces of microdroplets.
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Registered trials
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