ArticleJournal of computational neuroscience2019
Electrodiffusion models of synaptic potentials in dendritic spines.
Article in Journal of computational neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Accurate computation of ionic concentrations in the synaptic cleft requires the full Poisson-Nernst-Planck (PNP) equations.PLoS computational biology · 2026Article
- Spine-neck electrical bottlenecks tune temporal precision and inhibitory gating in cortical pyramidal neurons: A connectomics-based biophysical study.bioRxiv : the preprint server for biology · 2026Article
- How to train your neuron: developing a detailed, up-to-date, multipurpose model of hippocampal CA1 pyramidal cells.Frontiers in computational neuroscience · 2026Article
- Calcium dynamics in small spaces: Lessons learned from modeling in dendritic spines.Biophysical journal · 2025Review
- Contribution of individual excitatory synapses on dendritic spines to electrical signaling.Frontiers in neuroscience · 2025Article
- Differential behaviors of calcium-induced calcium release in one dimensional dendrite by Nernst-Planck equation, cable model and pure diffusion model.Cognitive neurodynamics · 2024Article
- Ion-concentration gradients induced by synaptic input increase the voltage depolarization in dendritic spines.Journal of computational neuroscience · 2024Article
- Electrical properties of dendritic spines.Biophysical journal · 2023Review
- Location of dopamine in lipid bilayers and its relevance to neuromodulator function.Biophysical journal · 2023Article
- Voltage compartmentalization in dendritic spines in vivo.Science (New York, N.Y.) · 2022Article
- Nanoscale molecular architecture controls calcium diffusion and ER replenishment in dendritic spines.Science advances · 2021Article
- Unique properties of dually innervated dendritic spines in pyramidal neurons of the somatosensory cortex uncovered by 3D correlative light and electron microscopy.PLoS biology · 2021Article
- An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.PLoS computational biology · 2021Article
- Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies.Developmental neurobiology · 2021Article
- Reply to 'Only negligible deviations from electroneutrality are expected in dendritic spines'.Nature reviews. Neuroscience · 2020Article
- Nanoscale Fluid Vortices and Nonlinear Electroosmotic Flow Drive Ion Current Rectification in the Presence of Concentration Gradients.The journal of physical chemistry. A · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The biophysical properties of dendritic spines play a critical role in neuronal integration but are still poorly understood, due to experimental difficulties in accessing them. Spine biophysics has been traditionally explored using theoretical models based on cable theory. However, cable theory generally assumes that concentration changes associated with ionic currents are negligible and, therefore, ignores electrodiffusion, i.e. the interaction between electric fields and ionic diffusion. This assumption, while true for large neuronal compartments, could be incorrect when applied to femto-liter size structures such as dendritic spines. To extend cable theory and explore electrodiffusion effects, we use here the Poisson (P) and Nernst-Planck (NP) equations, which relate electric field to charge and Fick's law of diffusion, to model ion concentration dynamics in spines receiving excitatory synaptic potentials (EPSPs). We use experimentally measured voltage transients from spines with nanoelectrodes to explore these dynamics with realistic parameters. We find that (i) passive diffusion and electrodiffusion jointly affect the dynamics of spine EPSPs; (ii) spine geometry plays a key role in shaping EPSPs; and, (iii) the spine-neck resistance dynamically decreases during EPSPs, leading to short-term synaptic facilitation. Our formulation, which complements and extends cable theory, can be easily adapted to model ionic biophysics in other nanoscale bio-compartments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.