Evidence map›Paper›PMID 31410626›Full record

ArticleSurgical endoscopy2020

Impact of needle-based confocal laser endomicroscopy on the therapeutic management of single pancreatic cystic lesions.

Maxime Palazzo, Alain Sauvanet, Rodica Gincul, Ivan Borbath, Goeffroy Vanbiervliet, Raphaël Bourdariat, Anne-Isabelle Lemaistre, Bertrand Pujol, Fabrice Caillol, Laurent Palazzo and 6 more

Registry-linked trialAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01563133 (Clinical Evaluation Of NCLE in The Lymph Nodes Along With Masses and Cystic Tumors of the Pancreas), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01563133 naunknown statusnot on this map

Clinical Evaluation Of NCLE in The Lymph Nodes Along With Masses and Cystic Tumors of the Pancreas

TypeinterventionalSponsorMauna Kea TechnologiesRan2012 to 2019Enrolled330ConditionsPancreatic Cyst, Pancreatic Neoplasms, Pancreatic Adenoma, Pancreatic CancerArmsEUS-FNA, nCLE
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maxime PalazzoHôpital Beaujon, Clichy, France.
Alain SauvanetHôpital Beaujon, Clichy, France.
Rodica GinculHôpital Privé Jean Mermoz, Ramsay Générale de Santé, 4 rue Jacqueline Auriol, 69008, Lyon, France.
Ivan BorbathCliniques Universitaires, Saint-Luc, Belgium.
Goeffroy VanbiervlietCentre Hospitalier Universitaire de l'Archet 2, Nice, France.
Raphaël BourdariatHôpital Privé Jean Mermoz, Ramsay Générale de Santé, 4 rue Jacqueline Auriol, 69008, Lyon, France.
Anne-Isabelle LemaistreBiomnis, Lyon, France.
Bertrand PujolHôpital Privé Jean Mermoz, Ramsay Générale de Santé, 4 rue Jacqueline Auriol, 69008, Lyon, France.
Fabrice CaillolInstitut Paoli Calmettes, Marseille, France.
Laurent PalazzoClinique du Trocadéro, Paris, France.
Alain AubertHôpital Beaujon, Clichy, France.
Frédérique MaireHôpital Beaujon, Clichy, France.
Louis BuscailHôpital Rangueil, Toulouse, France.
Marc GiovanniniInstitut Paoli Calmettes, Marseille, France.
Sébastien MarqueCapionis, Bordeaux, France.
Bertrand NapoléonHôpital Privé Jean Mermoz, Ramsay Générale de Santé, 4 rue Jacqueline Auriol, 69008, Lyon, France. bertrand.napoleon@dartybox.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe diagnosis and therapeutic management of large single pancreatic cystic lesions (PCLs) represent major issues for clinicians and essentially rely on endoscopic ultrasound fine-needle aspiration (EUS-FNA) findings. Needle-based confocal laser endomicroscopy (nCLE) has high diagnostic performance for PCLs. This study aimed to evaluate the impact of nCLE on the therapeutic management of patients with single PCLs.

methodsRetrospective and comparative study. Five independent pancreatic disease experts from tertiary hospitals independently reviewed data from a prospective database of 206 patients with single PCL, larger than 2 cm and who underwent EUS-FNA and nCLE. Two evaluations were performed. The first one included the sequential review of clinical information, EUS report and FNA results. The second one included the same data + nCLE report. Participants had to propose a therapeutic management for each case.

resultsThe addition of nCLE to EUS-FNA led to significant changes in therapeutic management for 28% of the patients (p < 0.001). nCLE significantly increased the interobserver agreement of 0.28 (p < 0.0001), from 0.36 (CI 95% 0.33-0.49) to 0.64 (CI 95% 0.61-0.67). nCLE improved the rates of full agreement among the five experts of 24% (p < 0.0001), from 30 to 54%. With nCLE, the surveillance rate of benign SCAs fell by 35%, from 40 (28/70) to 5% (4/76).

conclusionThe addition of nCLE to EUS-FNA significantly improves reliability of PCL diagnosis and could impact the therapeutic management of patients with single PCLs. ClinicalTrials.gov number, NCT01563133.

Indexed as

AdultDatabases, FactualEndoscopic Ultrasound-Guided Fine Needle AspirationEndoscopyFemaleHumansMaleMicroscopy, ConfocalMiddle AgedObserver VariationPancreasPancreatic CystProspective StudiesReproducibility of ResultsRetrospective StudiesEUS-FNANeedle-based confocal laser endomicroscopyPancreatic cysts

Identifiers

PMID31410626
PMCPMC7214514

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.