ArticleEuropean radiology2020
Early detection of heart function abnormality by native T1: a comparison of two T1 quantification methods.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- T2* assessment of the three coronary artery territories of the left ventricular wall by different monoexponential truncation methods.Magma (New York, N.Y.) · 2022Article
- Value of native T1 mapping in the prediction of major adverse cardiovascular events in hemodialysis patients.European radiology · 2022Article
- Cardiac TJournal of magnetic resonance imaging : JMRI · 2020Review
- Cardiovascular magnetic resonance (CMR) in restrictive cardiomyopathies.La Radiologia medica · 2020Review
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8 authors.
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Abstract
objectiveTo compare the robustness of native T1 mapping using mean and median pixel-wise quantification methods.
methodsFifty-seven consecutive patients without overt signs of heart failure were examined in clinical routine for suspicion of cardiomyopathy. MRI included the acquisition of native T1 maps by a motion-corrected modified Look-Locker inversion recovery sequence at 1.5 T. Heart function status according to four established volumetric left ventricular (LV) cardio MRI parameter thresholds was used for retrospective separation into subgroups of normal (n = 26) or abnormal heart function (n = 31). Statistical normality of pixel-wise T1 was tested on each myocardial segment and mean and median segmental T1 values were assessed.
resultsSegments with normally distributed pixel-wise T1 (57/58%) showed no difference between mean and median quantification in either patient group, while differences were highly significant (p < 0.001) for the respective 43/42% non-normally distributed segments. Heart function differentiation between two patient groups was significant in 14 myocardial segments (p < 0.001-0.040) by median quantification compared with six (p < 0.001-0.042) by using the mean. The differences by median quantification were observed between the native T1 values of the three coronary artery territories of normal heart function patients (p = 0.023) and insignificantly in the abnormal patients (p = 0.053).
conclusionMedian quantification increases the robustness of myocardial native T1 definition, regardless of statistical normality of the data. Compared with the currently prevailing method of mean quantification, differentiation between LV segments and coronary artery territories is better and allows for earlier detection of heart function impairment. KEY POINTS: • Median pixel-wise quantification of native T1 maps is robust and can be applied regardless of the statistical distribution of data points. • Median quantification is more sensitive to early heart function abnormality compared with mean quantification. • The new method yields significant native T1 value differentiation between the three coronary artery territories.
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