Evidence map›Paper›PMID 31410573›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2019

Redox-induced structural changes in the di-iron and di-manganese forms of Bacillus anthracis ribonucleotide reductase subunit NrdF suggest a mechanism for gating of radical access.

Kristīne Grāve, Wietske Lambert, Gustav Berggren, Julia J Griese, Matthew D Bennett, Derek T Logan, Martin Högbom

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Bacillus anthracis class Ib ribonucleotide reductase subunit NrdF intrinsically selects manganese over iron.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kristīne GrāveDepartment of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 10691, Stockholm, Sweden.
Wietske LambertPRA Health Sciences, Amerikaweg 18, 9407 TK, Assen, The Netherlands.
Gustav BerggrenDepartment of Chemistry, Ångström Laboratory, Uppsala University, Lägerhyddsvägen 1, 75120, Uppsala, Sweden.
Julia J GrieseDepartment of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 10691, Stockholm, Sweden.
Matthew D BennettDepartment of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 10691, Stockholm, Sweden.
Derek T LoganDepartment of Biochemistry and Structural Biology, Lund University, Box 124, 221 00, Lund, Sweden. derek.logan@biochemistry.lu.se.
Martin HögbomDepartment of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 10691, Stockholm, Sweden. hogbom@dbb.su.se.ORCID 0000-0001-5574-9383
Stockholm University · SEUppsala University · SELund University · SE

Funding

FP7 Research infrastructures 283570H2020 European Research Council 724394H2020 European Research Council HIGH-GEARKnut och Alice Wallenbergs Stiftelse 2017.0275Vetenskapsrådet 2017-04018
6 · The paper itself

Abstract

Class Ib ribonucleotide reductases (RNR) utilize a di-nuclear manganese or iron cofactor for reduction of superoxide or molecular oxygen, respectively. This generates a stable tyrosyl radical (Y·) in the R2 subunit (NrdF), which is further used for ribonucleotide reduction in the R1 subunit of RNR. Here, we report high-resolution crystal structures of Bacillus anthracis NrdF in the metal-free form (1.51 Å) and in complex with manganese (Mn

Indexed as

Bacillus anthracisCrystallography, X-RayFerritinsFlavin MononucleotideFMN ReductaseIronManganeseMetalloproteasesRibonucleotide ReductasesFerritinsFlavin MononucleotideFMN ReductaseIronManganeseMetalloproteasesRibonucleotide ReductasesCarboxylate shiftFerritin superfamilyMetalloproteinOxidoreductaseX-ray crystallography

Identifiers

PMID31410573
PMCPMC6754363
OpenAlexW2969134094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.