Evidence map›Paper›PMID 31410538›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

PET/MRI versus PET/CT in oncology: a prospective single-center study of 330 examinations focusing on implications for patient management and cost considerations.

Marius E Mayerhoefer, Helmut Prosch, Lucian Beer, Dietmar Tamandl, Thomas Beyer, Christoph Hoeller, Dominik Berzaczy, Markus Raderer, Matthias Preusser, Maximilian Hochmair and 14 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. [Frontiers in medicine · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. [European journal of nuclear medicine and molecular imaging · 2025
    Trial
  7. Head-to-head comparison of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. [American journal of nuclear medicine and molecular imaging · 2026
    Review
  14. Multimodality and temporal analysis of cervical cancer treatment response.Quantitative imaging in medicine and surgery · 2026
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Marius E MayerhoeferDepartment of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. marius.mayerhoefer@meduniwien.ac.at.ORCID 0000-0001-8786-8686
Helmut ProschDepartment of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Lucian BeerDepartment of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Dietmar TamandlDepartment of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Thomas BeyerCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Christoph HoellerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Dominik BerzaczyDepartment of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Markus RadererDepartment of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.
Matthias PreusserDepartment of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.
Maximilian HochmairDepartment of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Vienna, Austria.
Barbara KiesewetterDepartment of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.
Christian ScheubaDepartment of Surgery, Division of General Surgery, Medical University of Vienna, Vienna, Austria.
Ahmed Ba-SsalamahDepartment of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Georgios KaranikasDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Julia KesselbacherDepartment of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Gerald PragerDepartment of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.
Karin DieckmannDepartment of Radiation Oncology, Medical University of Vienna, Vienna, Austria.
Stephan PolterauerDepartment of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Michael WeberDepartment of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Ivo RauschCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Bernhard BraunerSiemens Healthineers, Siemens Healthcare Diagnostics GmbH, Vienna, Austria.
Harald EidherrDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Wolfgang WadsakDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Alexander R HaugDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposePET/MRI has recently been introduced into clinical practice. We prospectively investigated the clinical impact of PET/MRI compared with PET/CT, in a mixed population of cancer patients, and performed an economic evaluation of PET/MRI.

methodsCancer patients referred for routine staging or follow-up by PET/CT underwent consecutive PET/CT and PET/MRI, using single applications of [

resultsTwo hundred sixty-three patients (330 same-day PET/CT and PET/MRI examinations) were included. PET/MRI was accurate in 319/330 examinations and PET/CT in 277/330 examinations; the respective accuracies of 97.3% and 83.9% differed significantly (P < 0.001). The additional findings on PET/MRI-mainly liver and brain metastases-had implications for patient management in 21/263 patients (8.0%). The per-examination cost was 596.97 EUR for PET/MRI and 405.95 EUR for PET/CT. ICERs for PET/MRI were 14.26 EUR per percent of diagnostic accuracy and 23.88 EUR per percent of correctly managed patients.

conclusionsPET/MRI enables more appropriate management than PET/CT in a nonnegligible fraction of cancer patients. Since the per-examination cost is about 50% higher for PET/MRI than for PET/CT, a histology-based triage of patients to either PET/MRI or PET/CT may be meaningful.

Indexed as

Positron Emission Tomography Computed TomographyTomography, X-Ray ComputedFluorodeoxyglucose F18HumansMagnetic Resonance ImagingPositron-Emission TomographyProspective StudiesFluorodeoxyglucose F18CostsOncologyPatient managementPET/CTPET/MRI

Identifiers

PMID31410538
PMCPMC6885019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.