ArticleNeuroradiology2019
Dissociative changes in gray matter volume following electroconvulsive therapy in major depressive disorder: a longitudinal structural magnetic resonance imaging study.
Article in Neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.BMC medicine · 2025Pooled it
- Gray matter abnormalities in patients with major depressive disorder and social anxiety disorder: a voxel-based meta-analysis.Brain imaging and behavior · 2023Pooled it
- Meta-analytic Evidence for Volume Increases in the Medial Temporal Lobe After Electroconvulsive Therapy.Biological psychiatry · 2021Pooled it
- Disorganized Striatal Functional Connectivity as a Partially Shared Pathophysiological Mechanism in Both Schizophrenia and Major Depressive Disorder: A Transdiagnostic fMRI Study.Brain topography · 2025Article
- Two sides of the same coin: distinct neuroanatomical patterns predict crystallized and fluid intelligence in adults.Frontiers in neuroscience · 2023Article
- Changes in the amplitude of low-frequency fluctuations in specific frequency bands in major depressive disorder after electroconvulsive therapy.World journal of psychiatry · 2022Article
- The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go?Biological psychiatry · 2022Review
- Volumetric and functional connectivity alterations in patients with chronic cervical spondylotic pain.Neuroradiology · 2020Article
- Dopamine Multilocus Genetic Profile, Spontaneous Activity of Left Superior Temporal Gyrus, and Early Therapeutic Effect in Major Depressive Disorder.Frontiers in psychiatry · 2020Article
- Subcortical Brain Abnormalities and Clinical Relevance in Patients With Hemifacial Spasm.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeElectroconvulsive therapy (ECT), has become a widely applied potent treatment in clinical practice for major depressive disorder (MDD) over decades. However, due to its nonspecific and spatially unfocused nature, the underlying mechanisms of ECT remain unclear.
methodsIn this longitudinal study, 11 patients with MDD underwent magnetic resonance imaging (MRI) before and after ECT at three different time points. A longitudinal voxel-based morphology approach was performed to characterize dynamic changes in brain gray matter volume (GMV). Twelve age- and sex-matched healthy controls were recruited to identify structural brain changes of patients with MDD before and after ECT.
resultsThe brain GMV was globally found to increase shortly after a series of ECT, and then decrease 1 month after ECT treatment exposure. This fluctuating tendency was localized to the bilateral inferior parietal lobes, bilateral insula, and right superior temporal cortex. After the global GMV was corrected, there were only significant global effect increases in GMV in the left anterior hippocampus and right caudate, which were both significantly correlated with the improvement of depression symptoms. However, 1 month after ECT treatments, there was still significantly reduced GMV following patients with MDD compared to healthy controls in the left putamen, right anterior cingulate, and left inferior temporal cortex, which was observed before ECT.
conclusionsThese findings indicate that ECT in patients with MDD is closely associated with dissociative structural changes. The locally enhanced GMV in limbic areas may reflect that the ECT-related brain compensatory mechanisms contribute to brain structure recovery in MDD.
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