ArticleNature metabolism2019
The long noncoding RNA CHROME regulates cholesterol homeostasis in primate.
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Article in Nature metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.
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102citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
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Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.
- The Role of Long Noncoding RNAs in Cardiomyocyte Proliferation and Heart Regeneration After Myocardial Infarction: A Systematic Review.Cell transplantationPooled it
- OSBPL6 protects against demyelination and behavioral disorder via promoting cholesterol transport in oligodendrocyte.Journal of advanced research · 2026Article
- Genotype-dependent metabolic and inflammatory regulation at the ANRIL locus in human primary macrophages.Molecular genetics and genomics : MGG · 2026Article
- Non-coding RNAs in lipid metabolism and their roles in atherosclerosis.Nature reviews. Cardiology · 2026Review
- Pharmacology-Driven Dissection of Core Component Sets of Xuefu Zhuyu Decoction in Blood Stasis-Related Cardiovascular Diseases.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Molecular Mechanisms Underlying Atherosclerosis and Current Advances in Targeted Therapeutics.International journal of molecular sciences · 2026Review
- hLMR1, a hepatocyte-specific long noncoding RNA that represses amino acid catabolism through pre-mRNA interaction in human liver.PloS one · 2026Article
- The long noncoding RNAFrontiers in immunology · 2026Article
- Non-coding RNA-driven cardiovascular immunometabolic reprogramming: from inflammatory endotypes to therapeutic opportunities.Frontiers in cell and developmental biology · 2026Review
- RNA-Targeted Therapeutics for Lipid Metabolic Disorders: From Bench to Bedside.Research (Washington, D.C.) · 2026Article
- A cholesterol-responsive hepatic tRNA-derived small RNA regulates cholesterol homeostasis and atherosclerosis development.Nature communications · 2025Article
- Deciphering the enigma: long noncoding RNAs in disease pathogenesis and therapeutic prospects.Molecular and cellular biochemistry · 2025Review
- Review
- Cell type- and species-specific regulation of hepatic lncRNAs by TCDD-activated aryl hydrocarbon receptor.Scientific reports · 2025Article
- Advances in the Regulation of Lipid Metabolism by Non-Coding RNAs.Animals : an open access journal from MDPI · 2025Review
- Regulation of pyroptosis in diabetic nephropathy by long non-coding and circular RNAs.Clinical and experimental medicine · 2025Review
- The Multifaceted Roles ofNon-coding RNA · 2025Review
- Article
- Long noncoding RNAs in familial hypercholesterolemia: biomarkers, therapeutics, and AI in precision medicine.Lipids in health and disease · 2025Review
- Decreased protein activator of interferon induced protein kinase (PRKRA) involved in menopause-related cholesterol metabolic disorders by regulating cholesterol biosynthesis.Lipids in health and disease · 2025Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 11 institutions in 5 countries.
Elizabeth J Hennessy *Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
Coen van Solingen *Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
Kaitlyn R ScacalossiDepartment of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
Mireille OuimetDepartment of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
Milessa S AfonsoDepartment of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
Jurrien PrinsDepartment of Internal Medicine (Nephrology), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Graeme J KoelwynDepartment of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
Monika SharmaDepartment of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
Bhama RamkhelawonDepartment of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
Susan CarpenterDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, USA.
Albert BuschDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Ekaterina ChernogubovaDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Ljubica Perisic MaticDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Ulf HedinDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Lars MaegdefesselDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Brian E CaffreyMax Planck Institute for Molecular Genetics, Berlin, Germany.
Maryem A HusseinDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Emiliano P RicciINSERM U1111, Centre International de Recherche en Infectiologie, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France.
Ryan E TemelSaha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA.
Michael J GarabedianDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Jeffrey S BergerDepartment of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
Kasey C VickersDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA.
Matthew KankeDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University Ithaca, New York, USA.
Praveen SethupathyDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University Ithaca, New York, USA.
Daniel TeupserInstitute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
Lesca M HoldtInstitute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
Kathryn J MooreDepartment of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
New York University · USKarolinska Institutet · SECornell University · USLudwig-Maximilians-Universität München · DETUM Klinikum · DELeiden University Medical Center · NLMax Planck Institute for Molecular Genetics · DEUniversité Claude Bernard Lyon 1 · FRUniversity of California, Santa Cruz · USUniversity of Kentucky · USVanderbilt University Medical Center · US
Funding
Resolving Macrophage Inflammation in Atherosclerotic Plaques and Other Sites in Insulin ResistanceP01HL131481 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANN MARIE SCHMIDT · 2017 to 2026
$27.3MNon-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAVIES, SEAN STEPHEN · 2014 to 2025
$24.7MNon-coding RNA regulation of cholesterol homeostasis and atherosclerosisR35HL135799 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOORE, KATHRYN J · 2017 to 2023
$6.7MTraining Program in Cardiovascular SciencesT32HL098129 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Glenn I Fishman, Ira J Goldberg · 2009 to 2026
$5.9MEffects of Anti-miR-33 on Atherosclerosis Regression and RCT in Nonhuman PrimatesR01HL111932 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TEMEL, RYAN EUGENE · 2013 to 2017
$3.6MRETINAL MECHANISMS IN VISIONR01EY001711 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MACLEOD, DONALD I · 1985 to 2011
$3.2MPlatelet Activity & Cardiovascular Events following Vascular SurgeryR01HL114978 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BERGER, JEFFREY S · 2013 to 2017
$3.0MHDL and atherosclerosis regressionR01HL129433 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHER, EDWARD A, MOORE, KATHRYN J · 2016 to 2019
$2.4MHDL-microRNA Intercellular Communication in AtherosclerosisR01HL128996 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VICKERS, KASEY C · 2015 to 2019
$2.3MMacrophage SR-BI Regulates Autophagy, Angiogenin and tRNA-derived small RNAsR01HL127173 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LINTON, MACRAE F, VICKERS, KASEY C · 2016 to 2019
$2.1MRegulation of LXR alpha by glucose & cholesterol in diabetes & atherosclerosisR01HL117226 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHER, EDWARD A, GARABEDIAN, MICHAEL J. · 2014 to 2017
$2.1MmiR-33 Pathway Inhibition for Improving HDL FunctionalityR01HL119047 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOORE, KATHRYN J, RAYNER, KATEY · 2015 to 2018
$1.9MNEI NIH HHS R01 EY001711NHLBI NIH HHS K22 HL113039NHLBI NIH HHS P01 HL116263NHLBI NIH HHS P01 HL131481NHLBI NIH HHS P30 HL101270NHLBI NIH HHS R00 HL088528NHLBI NIH HHS R01 HL111932NHLBI NIH HHS R01 HL114978NHLBI NIH HHS R01 HL117226NHLBI NIH HHS R01 HL119047NHLBI NIH HHS R01 HL127173NHLBI NIH HHS R01 HL128996NHLBI NIH HHS R01 HL129433NHLBI NIH HHS R35 HL135799NHLBI NIH HHS T32 HL098129NIDDK NIH HHS R01 DK105965
Abstract
The human genome encodes thousands of long non-coding RNAs (lncRNAs), the majority of which are poorly conserved and uncharacterized. Here we identify a primate-specific lncRNA (
Indexed as
HomeostasisAnimalsAtherosclerosisCholesterolHepatocytesHumansLipid MetabolismLiver X ReceptorsMicroRNAsPrimatesRNA, Long NoncodingCholesterolLiver X ReceptorsMicroRNAsRNA, Long Noncoding
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