Evidence map›Paper›PMID 31410389›Full record

ArticleAging medicine (Milton (N.S.W))2018

Factors associated with medication adherence in older patients: A systematic review.

Ashley Smaje, Maryse Weston-Clark, Ranjana Raj, Mine Orlu, Daniel Davis, Mark Rawle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging medicine (Milton (N.S.W)), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Factors Associated with the Acceptability of Mass Drug Administration for Filariasis: A Systematic Review.International journal of environmental research and public health · 2022
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  16. A Demographic Look at Cancer Treatment Behaviors during the COVID-19 Pandemic.medRxiv : the preprint server for health sciences · 2026
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ashley SmajeUniversity College London Hospital NHS Trust, London, UK.
Maryse Weston-ClarkMRC Unit for Lifelong Health and Ageing at University College London, London, UK.
Ranjana RajKing's College London, London, UK.
Mine OrluUniversity College London School of Pharmacy, London, UK.
Daniel DavisMRC Unit for Lifelong Health and Ageing at University College London, London, UK.
Mark RawleMRC Unit for Lifelong Health and Ageing at University College London, London, UK.

Funding

Medical Research Council MC_UU_12019/1Wellcome Trust 107467Wellcome Trust 107467/Z/15/Z
6 · The paper itself

Abstract

objectiveMedication adherence is a major challenge in the treatment of older patients; however, they are under-represented in research. We undertook a systematic review focused on older patients to assess the reasons underlying non-adherence in this population.

methodsWe searched multiple electronic databases for studies reporting reasons for non-adherence to medication regimens in patients aged 75 years and over. Our results were not limited to specific diseases, health-care settings, or geographical locations. The quality of eligible studies was assessed using the Newcastle-Ottawa Scale. A narrative synthesis of findings was performed.

resultsA total of 25 publications were included, all of which were in community settings. Frequent medication review and knowledge regarding the purpose of the medication were positively associated with adherence. Factors associated with poor adherence were multimorbidity, cognitive impairment, complex regimens with multiple prescribing physicians, and problems with drug storage or formulation.

conclusionThese findings suggest that interventions to improve adherence could focus on medication review aimed at simplifying regimens and educating patients about their treatment. Groups with poor adherence that may benefit most from such a model include patients with multiple comorbidities and cognitive impairment.

Indexed as

drug prescriptionsgeriatric medicinepolypharmacy

Identifiers

PMID31410389
PMCPMC6692164

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.