ArticleNetwork neuroscience (Cambridge, Mass.)2019
Topological gene expression networks recapitulate brain anatomy and function.
Article in Network neuroscience (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Expression patterns of risk genes associated with three evolutionarily relevant syndromes in rhesus macaque and human brains.Translational psychiatry · 2026Article
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
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- Parkinson's disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes.Schizophrenia (Heidelberg, Germany) · 2024Article
- Altered topological structure of the brain white matter in maltreated children through topological data analysis.Network neuroscience (Cambridge, Mass.) · 2024Article
- Spatiotemporal expression patterns of anxiety disorder-associated genes.Translational psychiatry · 2023Article
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- The expanding horizons of network neuroscience: From description to prediction and control.NeuroImage · 2022Review
- NeuMapper: A scalable computational framework for multiscale exploration of the brain's dynamical organization.Network neuroscience (Cambridge, Mass.) · 2022Article
- Patterns of functional connectivity alterations induced by alcohol reflect somatostatin interneuron expression in the human cerebral cortex.Scientific reports · 2022Article
- Edges in brain networks: Contributions to models of structure and function.Network neuroscience (Cambridge, Mass.) · 2022Review
- Divergent connectomic organization delineates genetic evolutionary traits in the human brain.Scientific reports · 2021Article
- Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes.Scientific reports · 2021Article
- Gene-expression correlates of the oscillatory signatures supporting human episodic memory encoding.Nature neuroscience · 2021Article
- Homological scaffold via minimal homology bases.Scientific reports · 2021Article
- Editorial: Topological Neuroscience.Network neuroscience (Cambridge, Mass.) · 2019Article
- Multi-modal brain data exploration software for imaging transcriptomics: A comparative evaluation and future directions.Imaging neuroscience (Cambridge, Mass.)Article
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6 authors.
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Abstract
Understanding how gene expression translates to and affects human behavior is one of the ultimate goals of neuroscience. In this paper, we present a pipeline based on Mapper, a topological simplification tool, to analyze gene co-expression data. We first validate the method by reproducing key results from the literature on the Allen Human Brain Atlas and the correlations between resting-state fMRI and gene co-expression maps. We then analyze a dopamine-related gene set and find that co-expression networks produced by Mapper return a structure that matches the well-known anatomy of the dopaminergic pathway. Our results suggest that network based descriptions can be a powerful tool to explore the relationships between genetic pathways and their association with brain function and its perturbation due to illness and/or pharmacological challenges.
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