ArticleJournal of intensive care2019
Prognostic accuracy of SOFA, qSOFA and SIRS criteria in hematological cancer patients: a retrospective multicenter study.
Article in Journal of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Comparative Prognostic Performance of SOFA2.0 and SOFA for 28-Day Mortality in Patients Developing Sepsis During ECMO Support.Journal of inflammation research · 2026Article
- Characteristics and Outcomes of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections.Open forum infectious diseases · 2026Article
- Sphinganine inhibits macrophage polarization and protects against sepsis-induced intestinal injury.World journal of gastroenterology · 2025Article
- Explainable AI unravels sepsis heterogeneity via coagulation-inflammation profiles for prognosis and stratification.Nature communications · 2025Observational
- Targeted antineoplastic therapy in critically ill cancer patients: a multicenter analysis of the iCHOP registry.Annals of hematology · 2025Article
- 2024 update of the AGIHO guideline on diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients with solid tumours and hematological malignancies.The Lancet regional health. Europe · 2025Review
- Evaluation of prognostic factors for mortality in cancer patients with sepsis in the intensive care unit: systematic review protocol.Critical care science · 2025Article
- [Cancer patients in the emergency department].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Article
- Prognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings.Critical care (London, England) · 2024Observational
- Article
- Outcomes of patients with haematological malignancies and febrile neutropenia at the Universitas Academic Hospital multidisciplinary intensive care unit, Free State Province, South Africa.African journal of thoracic and critical care medicine · 2023Article
- Potential Role and Prognostic Value of Interleukin-15 for Mortality Among Elderly Patients with Sepsis.Journal of inflammation research · 2023Article
- Ability of a modified Sequential Organ Failure Assessment score to predict mortality among sepsis patients in a resource-limited setting.Acute and critical care · 2022Article
- Prognostic value of PaOThe Journal of international medical research · 2022Article
- A biomarker panel for risk of early respiratory failure following hematopoietic cell transplantation.Blood advances · 2022Article
- The Use of qSOFA, SOFA, and Ramathibodi Early Warning Score (REWS) to Predict Severe Complications in Hematologic Malignancy Patients.Open access emergency medicine : OAEM · 2022Article
- Outcomes and Risk Factors of Critically Ill Patients with Hematological Malignancy. Prospective Single-Centre Observational Study.Medicina (Kaunas, Lithuania) · 2021Observational
- Prognostic predictors in patients with sepsis after gastrointestinal tumor surgery: A retrospective study.World journal of gastrointestinal surgery · 2021Article
- [Bone marrow transplantation patients in the intensive care unit].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021Review
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith Sepsis-3, the increase in sequential organ failure assessment (SOFA) as a clinical score for the identification of patients with sepsis and quickSOFA (qSOFA) for the identification of patients at risk of sepsis outside the intensive care unit (ICU) were introduced in 2016. However, their validity has been questioned, and their applicability in different settings and subgroups, such as hematological cancer patients, remains unclear. We therefore assessed the validity of SOFA, qSOFA, and the systemic inflammatory response syndrome (SIRS) criteria regarding the diagnosis of sepsis and the prediction of in-hospital mortality in a multicenter cohort of hematological cancer patients treated on ICU and non-ICU settings.
methodsWe retrospectively calculated SIRS, SOFA, and qSOFA scores in our cohort and applied the definition of sepsis as "life-threatening organ dysfunction caused by dysregulated host response to infection" as reference. Discriminatory capacity was assessed using the area under the receiver operating characteristic curve (AUROC).
resultsAmong 450 patients with hematological cancer (median age 58 years, 274 males [61%]), 180 (40%) had sepsis of which 101 (56%) were treated on ICU. For the diagnosis of sepsis, sensitivity was 86%, 64%, and 42% for SIRS, SOFA, and qSOFA, respectively. However, the AUROCs of SOFA and qSOFA indicated better discrimination for sepsis than SIRS (SOFA, 0.69 [95% CI, 0.64-0.73]
conclusionsAn increase in SOFA score of ≥ 2 had better prognostic accuracy for both diagnosis of sepsis and in-hospital mortality in this setting, and especially on ICU, we observed limited validity of SIRS criteria and qSOFA in identifying hematological patients with sepsis and at high risk of death.
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