Evidence map›Paper›PMID 31410223›Full record

ArticleTheranostics2019

Unilateral Focused Ultrasound-Induced Blood-Brain Barrier Opening Reduces Phosphorylated Tau from The rTg4510 Mouse Model.

Maria Eleni Karakatsani, Tara Kugelman, Robin Ji, Maria Murillo, Shutao Wang, Yusuke Niimi, Scott A Small, Karen E Duff, Elisa E Konofagou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Characterization of microbubble cavitation in theranostic ultrasound-mediated blood-brain barrier opening for gene delivery.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
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  8. Focused ultrasound-mediated APOE4 knockdown in mouse brain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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  10. Article
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  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Maria Eleni KarakatsaniDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Tara KugelmanDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Robin JiDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Maria MurilloDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Shutao WangDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Yusuke NiimiDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Scott A SmallTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY 10032, USA.
Karen E DuffTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY 10032, USA.
Elisa E KonofagouDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Columbia University · US

Funding

Assessment of Ultrsound-facilitated Neurotherapeutics in Alzheimer's DiseaseR01AG038961 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2011 to 2020
$5.1M
Optimization of ultrasound-facilitated blood-brain barrier openingR01EB009041 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2008 to 2017
$4.4M
NIA NIH HHS R01 AG038961NIBIB NIH HHS R01 EB009041
6 · The paper itself

Abstract

The neuropathological hallmarks of Alzheimer's disease include amyloid plaques and neurofibrillary tangles. Tau pathology correlates well with impaired neuronal activity and dementia. Focused ultrasound coupled with systemic administration of microbubbles has previously been shown to open the blood-brain barrier and induce an immune response, which, in an amyloid AD mouse model, resulted in the reduction of the amyloid brain load.

Indexed as

Alzheimer DiseaseAnimalsBlood-Brain BarrierDisease Models, AnimalHippocampusMice, TransgenicRecombinant Proteinstau ProteinsTreatment OutcomeUltrasonographyMAPT protein, humanRecombinant Proteinstau ProteinsAlzheimer's diseaseblood-brain barrier openingfocused ultrasoundtau pathology

Identifiers

PMID31410223
PMCPMC6691580
OpenAlexW2963176170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.