Evidence map›Paper›PMID 31410199›Full record

ArticleTheranostics2019

Overcoming EZH2 Inhibitor Resistance by Taxane in PTEN-Mutated Cancer.

Linlin Ma, Yuqian Yan, Yang Bai, Yinhui Yang, Yunqian Pan, Xiaokun Gang, R Jeffrey Karnes, Jun Zhang, Qiubo Lv, Qiang Wu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  15. Theranostics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Linlin MaDepartment of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Yuqian YanDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Yang BaiDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Yinhui YangDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Yunqian PanDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Xiaokun GangDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
R Jeffrey KarnesDepartment of Urology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Jun ZhangDepartment of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Qiubo LvDepartment of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Qiang WuDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Haojie HuangDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Mayo Clinic · USBeijing Hospital · CNTongji Hospital · CNWinnMed · US

Funding

Role of proinflammatory cytokine-induced AR degradation in castration-resistant prostate cancerR01CA130908 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI HUANG, HAOJIE · 2010 to 2021
$3.5M
Role of FOXO1 Inactivation in Prostate TumorigenesisR01CA134514 · NCI · UNIVERSITY OF MINNESOTA · PI HUANG, HAOJIE · 2009 to 2019
$3.3M
Role of RUNX2 in prostate cancer intratumoral androgen synthesis and progressionR01CA193239 · NCI · MAYO CLINIC ROCHESTER · PI HUANG, HAOJIE · 2015 to 2019
$1.8M
Mechanism and role of aberrant AR activity in castration-resistant prostate cancerR01CA203849 · NCI · MAYO CLINIC ROCHESTER · PI HUANG, HAOJIE · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA130908NCI NIH HHS R01 CA134514NCI NIH HHS R01 CA193239NCI NIH HHS R01 CA203849
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug Resistance, NeoplasmAnimalsAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBridged-Ring CompoundsCell Line, TumorEnhancer of Zeste Homolog 2 ProteinForkhead Box Protein O1HumansMaleMiceMice, NudeMice, SCIDMutationPromoter Regions, GeneticProstatic Neoplasms3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazoliumAntineoplastic AgentsBridged-Ring CompoundsEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanForkhead Box Protein O1FOXO1 protein, humanPTEN PhosphohydrolasetaxaneTaxoidsTetrazolium SaltsThiazolescancercell deathEZH2FOXO1PTENtaxane

Identifiers

PMID31410199
PMCPMC6691386
OpenAlexW2964154526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.