ArticleInternational journal of chronic obstructive pulmonary disease2019
Quantitative CT analysis in patients with pulmonary emphysema: is lung function influenced by concomitant unspecific pulmonary fibrosis?
Article in International journal of chronic obstructive pulmonary disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 13 citations in OpenAlex.
- Strain analysis based on dynamic ventilation computed tomography in fibrotic interstitial lung disease and its correlation with pulmonary function tests.Quantitative imaging in medicine and surgery · 2026Article
- Impaired lung deformation during expiration in chronic obstructive pulmonary disease using four-dimensional dynamic-ventilation CT.Quantitative imaging in medicine and surgery · 2026Article
- Multi-modal evaluation of respiratory diaphragm motion in chronic obstructive pulmonary disease using MRI series and CT images.Japanese journal of radiology · 2024Article
- Review
- Relationship between the severity of emphysematous change in the lung and morbidity after esophagectomy for esophageal cancer: A retrospective study on a novel strategy for risk prediction.Thoracic cancer · 2024Article
- Use of machine learning models to predict prognosis of combined pulmonary fibrosis and emphysema in a Chinese population.BMC pulmonary medicine · 2022Article
- Chronic Obstructive Pulmonary Disease Combined with Interstitial Lung Disease.Tuberculosis and respiratory diseases · 2022Review
- Diagnostic efficacy of visual subtypes and low attenuation area based on HRCT in the diagnosis of COPD.BMC pulmonary medicine · 2022Article
- Quantitative CT parameters correlate with lung function in chronic obstructive pulmonary disease: A systematic review and meta-analysis.Frontiers in surgery · 2022Review
- Strain Analysis in Patients at High-Risk for COPD Using Four-Dimensional Dynamic-Ventilation CT.International journal of chronic obstructive pulmonary disease · 2022Article
- A Comparative Evaluation of Computed Tomography Images for the Classification of Spirometric Severity of the Chronic Obstructive Pulmonary Disease with Deep Learning.Diagnostics (Basel, Switzerland) · 2021Article
- Quantitative CT in mortality prediction in pulmonary fibrosis with or without emphysema.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2021Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Quantitative analysis of CT scans has proven to be a reproducible technique, which might help to understand the pathophysiology of chronic obstructive pulmonary disease (COPD) and combined pulmonary fibrosis and emphysema. The aim of this retrospective study was to find out if the lung function of patients with COPD with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages III or IV and pulmonary emphysema is measurably influenced by high attenuation areas as a correlate of concomitant unspecific fibrotic changes of lung parenchyma. Patients and methods: Eighty-eight patients with COPD GOLD stage III or IV underwent CT and pulmonary function tests. Quantitative CT analysis was performed to determine low attenuation volume (LAV) and high attenuation volume (HAV), which are considered to be equivalents of fibrotic (HAV) and emphysematous (LAV) changes of lung parenchyma. Both parameters were determined for the whole lung, as well as peripheral and central lung areas only. Multivariate regression analysis was used to correlate HAV with different parameters of lung function. Results: Unlike LAV, HAV did not show significant correlation with parameters of lung function. Even in patients with a relatively high HAV of more than 10%, in contrast to HAV ( Conclusion: In patients with COPD GOLD stage III-IV, emphysematous changes of lung parenchyma seem to have such a strong influence on lung function, which is a possible effect of concomitant unspecific fibrosis is overwhelmed.
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