ArticleMolecular psychiatry2020
Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia.
Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Glucose homeostasis and cognitive functions in schizophrenia: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Prevalent and characteristic alterations in blood-brain transcriptomic-functional imaging coupling in schizophrenia.Molecular psychiatry · 2026Article
- The distinct effects of metabolic syndrome on negative symptoms and on antipsychotic therapy of schizophrenia involve insular volume, functional connectivity, and genetic polymorphisms.Translational psychiatry · 2026Article
- [White matter microstructural disturbance and its relationship with cognitive function in schizophrenia with comorbidity of metabolic syndrome].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Deciphering the Heterogeneity of Schizophrenia: A Multimodal and Multivariate Neuroimaging Framework for Unveiling Brain-Symptom Relationships and Underlying Subtypes.Schizophrenia bulletin · 2026Article
- Risperidone reduces individualized morphometric similarity deviation in schizophrenia and associates with cortical transcriptomic patterns.Schizophrenia (Heidelberg, Germany) · 2026Article
- Gut microbial signatures in schizophrenia: exploring archaea, fungi, and bacteria.BMC psychiatry · 2026Article
- Unraveling the mysteries of schizophrenia: Insights into prefrontal cortex dysfunction and therapeutic implications.World journal of psychiatry · 2025Review
- Genetic signatures underlining circulating lipids display causal effects on schizophrenia.Scientific reports · 2025Article
- Neuronal alterations in AKT isotype expression in schizophrenia.Molecular psychiatry · 2025Article
- The role of cognitive function in predicting metabolic risk in schizophrenia: a multi-model comparison incorporating clinical features.Frontiers in psychiatry · 2025Article
- Interaction between baseline BMI and baseline disease severity predicts greater improvement in negative symptoms in first-episode schizophrenia.European archives of psychiatry and clinical neuroscience · 2024Article
- Resistance training boosts lactate transporters and synaptic proteins in insulin-resistance mice.Heliyon · 2024Article
- Analysis of Intestinal Microbiota in Schizophrenic Patients with Type 2 Diabetes Mellitus.Alpha psychiatry · 2024Article
- The relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- The Bidirectional Relationship between Weight Gain and Cognitive Function in First-Episode Schizophrenia: A Longitudinal Study in China.Brain sciences · 2024Article
- Neuronal alterations in AKT isotype expression in schizophrenia.Research square · 2024Article
- Association between psychiatric symptoms with multiple peripheral blood sample test: a 10-year retrospective study.Frontiers in psychiatry · 2024Article
- Glucose Metabolism and Sex Hormones in Male Patients with Medication-naïve First-episode Schizophrenia: A Large-scale Cross-sectional Study.Current neuropharmacology · 2024Article
- Association of Alexithymia With Positive Symptoms in Chinese Chronic Schizophrenia Patients With and Without Obesity.Psychiatry investigation · 2023Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disturbance of glucose metabolism may be implicated in cognitive deficits of schizophrenia in its early phases. Many studies have reported the important role of widespread disruption of white matter (WM) connectivity in pathogenesis, cognitive deficit and psychopathology of schizophrenia. However, no study has investigated their inter-relationships in drug-naive first episode (DNFE) patients with schizophrenia. Glucose metabolism parameters including fasting glucose, insulin and homeostasis model of assessment-insulin resistance (HOMA-IR) index, cognitive performance on the MATRICS Consensus Cognitive Battery (MCCB) and the voxel-wised WM fractional anisotropy (FA) values were examined using DTI in 39 DNFE schizophrenia and 31 control subjects. The Positive and Negative Syndrome Scale was utilized for clinical symptoms. The patients showed significantly greater fasting plasma levels of glucose and insulin and HOMA-IR, and poorer cognitive scores, together with widespread reduced FA values in five brain areas, including left and right corpus callosum, superior longitudinal fasciculus, posterior thalamic radiation, and corona radiata (all p < 0.05). Association analysis showed that glucose level was positively associated with Digital Sequence Test and Continuous Performance Test, but negatively with FA values in posterior thalamic radiation and left corpus callosum in patients (all p < 0.05). Furthermore, multiple regression analysis revealed that the interactions of glucose × FA in left corpus callosum, longitudinal fasciculus and corona radiata were independent contributors to the Brief Visuospatial Memory Test (BVMT) of MCCB, while the interaction of glucose × FA in left corpus callosum, or in longitudinal fasciculus was associated with MCCB mazes and Trail Making A Test, respectively. Therefore, abnormal glucose metabolism, cognitive impairment and widespread disruption of WM structure occur in an early course of schizophrenia onset. An interaction between glucose metabolism abnormality and the WM dysconnectivity may lead to cognitive impairment.
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