ArticleScientific reports2019
Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- LIN-23 AffectsbioRxiv : the preprint server for biology · 2026Article
- Beyond KEAP1: The Context-Specific NRF2 Partner Code in Disease and Therapy.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- Promising tools into oxidative stress: A review of non-rodent model organisms.Redox biology · 2024Review
- Hepatic WDR23 proteostasis mediates insulin homeostasis by regulating insulin-degrading enzyme capacity.GeroScience · 2024Article
- Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy.Nature communications · 2024Article
- WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.Mechanisms of ageing and development · 2024Article
- Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain.Cellular signalling · 2024Article
- Disrupting the SKN-1 homeostat: mechanistic insights and phenotypic outcomes.Frontiers in aging · 2024Review
- A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation.GeroScience · 2023Article
- Genetic variation ineLife · 2022Article
- University of Southern California and buck institute nathan shock center: multidimensional models of aging.GeroScience · 2021Article
- An Overview of the Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases.International journal of molecular sciences · 2021Review
- Maf1 regulates intracellular lipid homeostasis in response to DNA damage response activation.Molecular biology of the cell · 2021Article
- Sp1 is a substrate of Keap1 and regulates the activity of CRL4AThe Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Maintaining a healthy cellular environment requires the constant control of proteostasis. E3 ubiquitin ligase complexes facilitate the post-translational addition of ubiquitin, which based on the quantity and specific lysine linkages, results in different outcomes. Our studies reveal the CUL4-DDB1 substrate receptor, WDR23, as both a positive and a negative regulator in cellular stress responses. These opposing roles are mediated by two distinct isoforms: WDR-23A in the cytoplasm and WDR-23B in the nucleus. C. elegans expressing only WDR-23A display activation of SKN-1 and enhanced survival to oxidative stress, whereas animals with restricted WDR-23B expression do not. Additionally, we identify GEN-1, a Holliday junction resolvase, as an evolutionarily conserved WDR-23 substrate and find that the nuclear and cytoplasmic isoforms of WDR-23 differentially affect double-strand break repair. Our results suggest that through differential ubiquitination, nuclear WDR-23B inhibits the activity of substrates, most likely by promoting protein turnover, while cytoplasmic WDR-23A performs a proteasome-independent role. Together, our results establish a cooperative role between two spatially distinct isoforms of WDR-23 in ensuring proper regulation of WDR-23 substrates.
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