ArticleScientific reports2019
Cerumenogram: a new frontier in cancer diagnosis in humans.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Evaluation of earwax and hair cortisol concentration in relation to environmental stressors in Hanwoo cattle.Veterinary research communications · 2025Article
- Cerumenogram as an assay for the metabolic diagnosis of precancer, cancer, and cancer remission.Scientific reports · 2025Article
- Effect of organic solvents on earwax cortisol extraction in Hanwoo cattle.Journal of animal science and technology · 2024Article
- The human volatilome meets cancer diagnostics: past, present, and future of noninvasive applications.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Mass Spectrometric Interrogation of Earwax: Toward the Detection of Ménière's Disease.ACS omega · 2023Article
- In Vitro Antitumor and Anti-Inflammatory Activities ofNutrients · 2023Article
- A cerumenolomic approach to bovine trypanosomosis diagnosis.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Beyond liquid biopsy: Toward non-invasive assays for distanced cancer diagnostics in pandemics.Biosensors & bioelectronics · 2022Review
- Article
- Analysis of urinary VOCs using mass spectrometric methods to diagnose cancer: A review.Clinical mass spectrometry (Del Mar, Calif.) · 2020Review
- Low Molecular Weight Volatile Organic Compounds Indicate Grazing by the Marine RotiferMetabolites · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is the deadliest human disease and the development of new diagnosis methods is important to increase the chances of a cure. In this work it was developed a new method, named here for the first time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples collected from cancer patients (cancer group) and cancer-free patients (control group) were analyzed by Headspace/Gas Chromatography-Mass Spectrometry (HS/GC-MS), following with multivariate analysis steps to process the raw data generated. In total, 158 volatile organic metabolites (VOMs) were identified in the cerumen samples. The 27 selected as potential VOMs biomarkers for cancer provided 100% discrimination between the cancer and control groups. This new test can thus be routinely employed for cancer diagnoses that is non-invasive, fast, cheap, and highly accurate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.