ArticleNature communications2019
Studying nucleic envelope and plasma membrane mechanics of eukaryotic cells using confocal reflectance interferometric microscopy.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Single Cell Mechanics in Disease Progression.Small science · 2026Review
- Quantifying 3D live-cell membrane dynamics using dynamic metal-induced energy transfer spectroscopy (dynaMIET).Science advances · 2026Article
- Scanless temporal focusing enables high-speed three-dimensional quantitative phase microscopy.Research square · 2026Article
- Scanless temporal focusing enables high-speed three-dimensional quantitative phase microscopy.bioRxiv : the preprint server for biology · 2026Article
- Ultrafast tomograms in a flash.Science advances · 2025Review
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part II.Journal of biomedical optics · 2024Review
- Confocal interferometric scattering microscopy reveals 3D nanoscopic structure and dynamics in live cells.Nature communications · 2023Article
- Artificial confocal microscopy for deep label-free imaging.Nature photonics · 2023Article
- Measurement of the low-frequency charge noise of bacteria.Physical review. E · 2022Article
- Single-Shot Quantitative Polarization Imaging of Complex Birefringent Structure Dynamics.ACS photonics · 2021Article
- The effect of pupil transmittance on axial resolution of reflection phase microscopy.Scientific reports · 2021Article
- Tumor cell nuclei soften during transendothelial migration.Journal of biomechanics · 2021Article
- Single-cell cytometry via multiplexed fluorescence prediction by label-free reflectance microscopy.Science advances · 2021Article
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Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Mechanical stress on eukaryotic nucleus has been implicated in a diverse range of diseases including muscular dystrophy and cancer metastasis. Today, there are very few non-perturbative methods to quantify nuclear mechanical properties. Interferometric microscopy, also known as quantitative phase microscopy (QPM), is a powerful tool for studying red blood cell biomechanics. The existing QPM tools, however, have not been utilized to study biomechanics of complex eukaryotic cells either due to lack of depth sectioning, limited phase measurement sensitivity, or both. Here, we present depth-resolved confocal reflectance interferometric microscopy as the next generation QPM to study nuclear and plasma membrane biomechanics. The proposed system features multiple confocal scanning foci, affording 1.5 micron depth-resolution and millisecond frame rate. Furthermore, a near common-path interferometer enables quantifying nanometer-scale membrane fluctuations with better than 200 picometers sensitivity. Our results present accurate quantification of nucleic envelope and plasma membrane fluctuations in embryonic stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.