ArticleScientific reports2019
Glioblastoma multiforme restructures the topological connectivity of cerebrovascular networks.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Bridging tumor biology and radiomics through an ultra-large physics-driven vascular model.npj biomedical innovations · 2026Article
- Radiomics model integrating MRI and ECV enhances prediction accuracy for progression in high-grade glioma.NPJ precision oncology · 2026Article
- Fractal analysis of hepatocellular carcinoma vasculature shows regional differences independent of vascular invasion.Scientific reports · 2026Article
- Nanoparticle‑based delivery systems for targeted therapy in brain tumors: Progress, challenges and perspectives (Review).International journal of oncology · 2025Review
- Whole-Brain Vascular Architecture Mapping Identifies Region-Specific Microvascular Profiles In Vivo.AJNR. American journal of neuroradiology · 2024Article
- Review
- Biomaterial-basedCancer pathogenesis and therapy · 2023Review
- Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem.Nature communications · 2023Article
- Non-Invasive 3D Photoacoustic Tomography of Angiographic Anatomy and Hemodynamics of Fatty Livers in Rats.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Advanced Computational Methods to Evaluate Vascular Heterogeneity in Tumor Tissue Based on Single Plane Illumination Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Imaging in translational cancer research.Cancer biology & medicine · 2022Review
- Neural Regulation of Cancer: Cancer-Induced Remodeling of the Central Nervous System.Advanced biology · 2022Review
- A Workflow for Three-Dimensional Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network.Journal of biomechanical engineering · 2022Article
- Open-source analysis and visualization of segmented vasculature datasets with VesselVio.Cell reports methods · 2022Article
- Large-scale characterization of the microvascular geometry in development and disease by tissue clearing and quantitative ultramicroscopy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Assessment of Vascular Network Connectivity of Hepatocellular Carcinoma Using Graph-Based Approach.Frontiers in oncology · 2021Article
- Brain tumor vessels-a barrier for drug delivery.Cancer metastasis reviews · 2020Review
- Hemisphere-Specific Functional Remodeling and Its Relevance to Tumor Malignancy of Cerebral Glioma Based on Resting-State Functional Network Analysis.Frontiers in neuroscience · 2020Article
- Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma multiforme alters healthy tissue vasculature by inducing angiogenesis and vascular remodeling. To fully comprehend the structural and functional properties of the resulting vascular network, it needs to be studied collectively by considering both geometric and topological properties. Utilizing Single Plane Illumination Microscopy (SPIM), the detailed capillary structure in entire healthy and tumor-bearing mouse brains could be resolved in three dimensions. At the scale of the smallest capillaries, the entire vascular systems of bulk U87- and GL261-glioblastoma xenografts, their respective cores, and healthy brain hemispheres were modeled as complex networks and quantified with fundamental topological measures. All individual vessel segments were further quantified geometrically and modular clusters were uncovered and characterized as meta-networks, facilitating an analysis of large-scale connectivity. An inclusive comparison of large tissue sections revealed that geometric properties of individual vessels were altered in glioblastoma in a relatively subtle way, with high intra- and inter-tumor heterogeneity, compared to the impact on the vessel connectivity. A network topology analysis revealed a clear decomposition of large modular structures and hierarchical network organization, while preserving most fundamental topological classifications, in both tumor models with distinct growth patterns. These results augment our understanding of cerebrovascular networks and offer a topological assessment of glioma-induced vascular remodeling. The findings may help understand the emergence of hypoxia and necrosis, and prove valuable for therapeutic interventions such as radiation or antiangiogenic therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.