SynthesisNature communications2019
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
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149citing papers in PubMed, 5 pooled it
22.4field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
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Who cites it
149 citing papers in PubMed, 5 syntheses or guidelines pooled it, 245 citations in OpenAlex.
- Associations between sleep traits and colorectal cancer: a mendelian randomization analysis.Frontiers in oncology · 2025Pooled it
- Establishing causal relationships between sleep and adiposity traits using Mendelian randomization.Obesity (Silver Spring, Md.) · 2023Pooled it
- Putative Animal Models of Restless Legs Syndrome: A Systematic Review and Evaluation of Their Face and Construct Validity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Pooled it
- Longitudinal associations of DNA methylation and sleep in children: a meta-analysis.Clinical epigenetics · 2022Pooled it
- The causal relationship between sleep traits and the risk of schizophrenia: a two-sample bidirectional Mendelian randomization study.BMC psychiatry · 2022Pooled it
- Effects of optimal timed automatic awakening from a short daytime nap on cognitive performance, alertness, and fatigue.Scientific reports · 2025Trial
- Molecular correlates of sleep deprivation in the mouse brain identified by meta-analysis of microarray data.Neurobiology of sleep and circadian rhythms · 2026Article
- Genetically supported targets and drug repurposing for sleep disorders: a Mendelian randomization systematic study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Mitochondrial Function-Related Genes in Sleep Disorders: A Multi-Omics Mendelian Randomization Study.Journal of molecular neuroscience : MN · 2026Article
- Emerging genetics of sleep and circadian disorders.Current opinion in pediatrics · 2026Article
- Dissecting the shared genetic architecture and biological mechanisms linking sleep traits and suicide attempts: from variants to genes.Molecular psychiatry · 2026Article
- Associations of excessive sleepiness with sleep apnea physiological endo-phenotypes: the multi-ethnic study of atherosclerosis.Annals of the American Thoracic Society · 2026Article
- Rare Coding Variants Reveal Distinct Genetic Architectures Across Multidimensional Sleep Phenotypes.medRxiv : the preprint server for health sciences · 2026Article
- Cross-trait clustering of sub-threshold sleep genetic signals identifies EGR2 as a conserved regulator of sleep.bioRxiv : the preprint server for biology · 2026Article
- Plasma proteomics of sleep traits reveals systemic immune-metabolic pathways and genetically prioritized proteins.Molecular psychiatry · 2026Article
- Sleep and dementia: Assessing established dementia-related factors using multivariable Mendelian randomization.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body.Communications medicine · 2026Article
- Meta-analysis of Cannabis Use Identifies Shared Genetic Loci with Sleep and Circadian Rhythms.medRxiv : the preprint server for health sciences · 2026Article
- Investigating the causal role of sleep disorders in anorexia nervosa and obsessive-compulsive disorder: a bidirectional Mendelian randomization study.Eating and weight disorders : EWD · 2026Article
- Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleep.bioRxiv : the preprint server for biology · 2026Article
89 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
45 authors at 17 institutions in 7 countries.
Heming WangDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1486-7495
Jacqueline M LaneProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Samuel E JonesGenetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom.ORCID http://orcid.org/0000-0003-0153-922X
Hassan S DashtiProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1650-679X
Hanna M OllilaProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom.
Vincent T van HeesNetherlands eScience Center, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0003-0182-9008
Ben BrumptonK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0002-3058-1059
Bendik S WinsvoldK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-4171-8919
Katri KantojärviGenomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland.
Teemu PalviainenInstitute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7847-8384
Brian E CadeDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Tamar SoferDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8520-8860
Yanwei SongCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2411-6548
Krunal PatelCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Simon G AndersonDivision of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-8896-073X
David A BechtoldDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-8676-8704
Jack BowdenMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Richard EmsleyDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Simon D KyleSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Max A LittleDepartment of Mathematics, Aston University, Birmingham, UK.
Andrew S LoudonDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Frank A J L ScheerDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2014-7582
Shaun M PurcellDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Rebecca C RichmondMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-0574-5071
Kai SpiegelhalderClinic for Psychiatry and Psychotherapy, Medical Centre, University of Freiburg, Freiburg, Germany.
Jessica TyrrellGenetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom.ORCID http://orcid.org/0000-0002-9256-6065
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Christer HublinInstitute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
Jaakko A KaprioInstitute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Kati KristianssonGenomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland.ORCID http://orcid.org/0000-0003-4688-107X
Sonja SulkavaGenomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland.
Tiina PaunioGenomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland.
Kristian HveemK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Jonas B NielsenDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
Cristen J WillerDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5645-4966
John-Anker ZwartDivision of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.
Linn B StrandK.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom.
David RayNIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX39DU, UK.
Deborah A LawlorMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-6793-2262
Martin K RutterDivision of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom.
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Richa SaxenaDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. rsaxena@partners.org.ORCID http://orcid.org/0000-0003-2233-1065
Broad Institute · USUniversity of Helsinki · FIUniversity of Exeter · GBUniversity of Manchester · GBNorwegian University of Science and Technology · NOUniversity of Bristol · GBNortheastern University · USOslo University Hospital · NOUniversity of Michigan · USAston University · GBCase Western Reserve University · USFinnish Institute for Health and Welfare · FIJohn Radcliffe Hospital · GBManchester Academic Health Science Centre · GBNetherlands eScience Center · NLUniversity of Freiburg · DEUniversity of Oxford · GB
Funding
Using genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3MPhenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2MBIOMETRIC-GENETIC ANALYSIS OF CARDIOVASCULAR DISEASET32HL007567 · NHLBI · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI ZHU, XIAOFENG · 1985 to 2021
$6.0MUsing Genetics to Inform Mechanism of Cardiovascular DiseaseR35HL135824 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J · 2017 to 2022
$5.4MLeveraging Family Data to Identify Genetic Variants for Sleep ApneaR01HL113338 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIN, XIHONG, REDLINE, SUSAN S. · 2012 to 2016
$4.4MGenetics of chronotype and impact on metabolic diseaseR01DK107859 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2016 to 2026
$4.0MMelatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK102696 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2015 to 2019
$3.8MStatistical methods for analyzing high-throughput genotype dataR01HG003054 · NHGRI · LOYOLA UNIVERSITY CHICAGO · PI ZHU, XIAOFENG · 2005 to 2017
$3.6MImpact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2MGenetic and molecular basis of circadian rhythm disordersK01HL136884 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2018 to 2022
$848kWhole Genomic Characterization of Sleep Apnea Traits and Comorbid DisordersK01HL135405 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CADE, BRIAN EDMAND · 2017 to 2020
$695kImpact of genetic variants on sleep timing and type 2 diabetes riskF32DK102323 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2015 to 2016
$116kMedical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00011/2Medical Research Council MC_UU_00011/3Medical Research Council MC_UU_00011/6Medical Research Council MR/M005070/1Medical Research Council MR/M008908/1Medical Research Council MR/P012167/1Medical Research Council MR/P023576/1Medical Research Council MR/P023576/2NHGRI NIH HHS R01 HG003054NHLBI NIH HHS K01 HL135405NHLBI NIH HHS K01 HL136884NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R35 HL135818NHLBI NIH HHS R35 HL135824NHLBI NIH HHS T32 HL007567NIDDK NIH HHS F32 DK102323NIDDK NIH HHS R01 DK102696NIDDK NIH HHS R01 DK105072NIDDK NIH HHS R01 DK107859Wellcome Trust 107851/Z/15/Z
Abstract
Excessive daytime sleepiness (EDS) affects 10-20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs syndrome, insomnia) and sleep traits (duration, chronotype, accelerometer-derived sleep efficiency and daytime naps or inactivity). However, individual daytime sleepiness signals vary in their associations with objective short vs long sleep, and with markers of sleep continuity. The 42 sleepiness variants primarily cluster into two predominant composite biological subtypes - sleep propensity and sleep fragmentation. Shared genetic links are also seen with obesity, coronary heart disease, psychiatric diseases, cognitive traits and reproductive ageing.
Indexed as
Genetic LociSleepinessAdultAgedAge FactorsDatasets as TopicFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotidePolysomnographySelf ReportSex FactorsSleep
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