ArticleNature communications2019
GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies.Journal of the American Heart Association · 2023Pooled it
- Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study.Frontiers in endocrinology · 2023Pooled it
- Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies Suggestive Loci for Sodium Intake, Potassium Intake, and Their Ratio Measured from 24-Hour or Half-Day Urine Samples.The Journal of nutrition · 2020Pooled it
- Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank.Molecular psychiatry · 2026Article
- Mapping the role of macro and micronutrients in bone mineral density: a comprehensive Mendelian randomization study.European journal of nutrition · 2025Article
- Article
- Second-order group knockoffs with applications to genome-wide association studies.Bioinformatics (Oxford, England) · 2024Article
- Associations of E-proteinoid 3 receptor genetic polymorphisms with salt sensitivity, longitudinal blood pressure changes, and hypertension incidence in Chinese adults.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study.Sexual medicine · 2024Article
- ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits.Cell metabolism · 2024Article
- SGLT2 inhibition, plasma proteins, and heart failure: a proteome-wide Mendelian Randomization and colocalization study.Frontiers in cardiovascular medicine · 2024Article
- Kidney function may partially mediated the protective effect of urinary uromodulin on kidney stone.Urolithiasis · 2023Article
- Association between urinary sodium and circulating lipid levels: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression.Nature communications · 2022Article
- Urinary Sodium Excretion Enhances the Effect of Alcohol on Blood Pressure.Healthcare (Basel, Switzerland) · 2022Article
- The impact of excessive salt intake on human health.Nature reviews. Nephrology · 2022Review
- Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments.Nature genetics · 2021Article
- Estimated salt intake and risk of atrial fibrillation in a prospective community-based cohort.Journal of internal medicine · 2021Observational
- The reference genome and transcriptome of the limestone langur, Trachypithecus leucocephalus, reveal expansion of genes related to alkali tolerance.BMC biology · 2021Article
- Approaches to Integrating Metabolomics and Multi-Omics Data: A Primer.Metabolites · 2021Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary sodium and potassium excretion using data from 446,237 individuals of European descent from the UK Biobank study. We extensively interrogate the results using multiple analyses such as Mendelian randomization, functional assessment, co localization, genetic risk score, and pathway analyses. We identify a shared genetic component between urinary sodium and potassium expression and cardiovascular traits. Ingenuity pathway analysis shows that urinary sodium and potassium excretion loci are over-represented in behavioural response to stimuli. Our study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.