Evidence map›Paper›PMID 31409775›Full record

ArticleCell death & disease2019

Long noncoding RNA ABHD11-AS1 functions as a competing endogenous RNA to regulate papillary thyroid cancer progression by miR-199a-5p/SLC1A5 axis.

Xi Zhuang, Houchao Tong, Yu Ding, Luyao Wu, Jingsheng Cai, Yan Si, Hao Zhang, Meiping Shen

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  15. [Long non-coding RNA ABHD11-AS1 promotes glycolysis in gastric cancer cells to accelerate tumor progression].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
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  20. LncRNA ABHD11-AS1 promotes tumor progression in papillary thyroid carcinoma by regulating EPS15L1/EGFR signaling pathway.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xi ZhuangDepartment of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, PR China.
Houchao TongDepartment of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, PR China.
Yu DingDepartment of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, PR China.
Luyao WuDepartment of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, PR China.
Jingsheng CaiDepartment of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, PR China.
Yan SiDepartment of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, PR China.
Hao ZhangDepartment of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, PR China.
Meiping ShenDepartment of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, PR China. shenmeiping@jsph.org.cn.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the increasing incidence of papillary thyroid cancer (PTC), more attention has been paid to exploring the mechanism of PTC initiation and progression. In addition, ectopic expression of long noncoding RNAs (lncRNAs) is reported to play a pivotal role in multiple human cancers. Based on these findings, we examined lncRNA ABHD11 antisense RNA 1 (ABHD11-AS1) expression and its clinical significance, biological function and mechanism in PTC. First, we analyzed thyroid ABHD11-AS1 expression in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Then, qRT-PCR was applied to detect the expression in paired PTC tissues and adjacent normal tissues, as well as in PTC cell lines (TPC-1 and K-1) and a normal thyroid follicular epithelium cell line (Nthy-ori3-1). In addition, we validated the relationship between ABHD11-AS1 expression and clinicopathological features by the Pearson X

Indexed as

AgedAmino Acid Transport System ASCCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMicroRNAsMiddle AgedMinor Histocompatibility AntigensProgression-Free SurvivalRNA, AntisenseRNA, Long NoncodingSerine ProteasesSignal TransductionABHD11 protein, humanAmino Acid Transport System ASCMicroRNAsMinor Histocompatibility Antigensmirn199 microRNA, humanRNA, AntisenseRNA, Long NoncodingSerine ProteasesSLC1A5 protein, human

Identifiers

PMID31409775
PMCPMC6692390
OpenAlexW2967551305

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.