Evidence map›Paper›PMID 31409739›Full record

ArticleJournal of lipid research2019

Characterization of ANGPTL4 function in macrophages and adipocytes using

Antwi-Boasiako Oteng, Philip M M Ruppert, Lily Boutens, Wieneke Dijk, Xanthe A M H van Dierendonck, Gunilla Olivecrona, Rinke Stienstra, Sander Kersten

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  3. Article
  4. Review
  5. New approaches to triglyceride reduction: Is there any hope left?American journal of preventive cardiology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice.American journal of physiology. Endocrinology and metabolism · 2021
    Article
  12. Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8.American journal of physiology. Endocrinology and metabolism · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. The Pathogenic Role of Long Non-coding RNA H19 in AtherosclerosisFrontiers in cardiovascular medicine · 2021
    Article
  19. PPARβ/δ Agonist Alleviates Diabetic OsteoporosisFrontiers in cell and developmental biology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Antwi-Boasiako OtengNutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Philip M M RuppertNutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Lily BoutensNutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Wieneke DijkNutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Xanthe A M H van DierendonckNutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Gunilla OlivecronaDepartment of Medical Biosciences/Physiological Chemistry, Umeå University, Umeå, Sweden.
Rinke StienstraNutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Sander KerstenNutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands sander.kersten@wur.nl.
Wageningen University & Research · NLRadboud University Nijmegen · NLUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiopoietin-like protein (ANGPTL)4 regulates plasma lipids, making it an attractive target for correcting dyslipidemia. However, ANGPTL4 inactivation in mice fed a high fat diet causes chylous ascites, an acute-phase response, and mesenteric lymphadenopathy. Here, we studied the role of ANGPTL4 in lipid uptake in macrophages and in the above-mentioned pathologies using

Indexed as

Gene Knockout TechniquesAdipocytesAngiopoietin-Like Protein 4AnimalsCell RespirationChylous AscitesExonsGene Expression RegulationLipoprotein LipaseLymphadenopathyMacrophagesMiceMice, Inbred C57BLTriglyceridesAngiopoietin-Like Protein 4Lipoprotein LipaseTriglyceridesangiopoietin-like protein 4dyslipidemiaglucose homeostasisinflammationlipoprotein lipasemacrophage foam cells

Identifiers

PMID31409739
PMCPMC6795085
OpenAlexW2968121647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.