Evidence map›Paper›PMID 31409704›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Essential

Anjana Srivatsan, Binzhong Li, Dafne N Sanchez, Steven B Somach, Vandeclecio L da Silva, Sandro J de Souza, Christopher D Putnam, Richard D Kolodner

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Anjana SrivatsanLudwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, CA 92093-0669.
Binzhong LiLudwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, CA 92093-0669.
Dafne N SanchezLudwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, CA 92093-0669.
Steven B SomachLudwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, CA 92093-0669.
Vandeclecio L da SilvaBioinformatics Multidisciplinary Environment, Instituto Metrópole Digital-Universidade Federal do Rio Grande do Norte, Natal, Brazil 59082-180.
Sandro J de SouzaBioinformatics Multidisciplinary Environment, Instituto Metrópole Digital-Universidade Federal do Rio Grande do Norte, Natal, Brazil 59082-180.
Christopher D PutnamLudwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, CA 92093-0669.
Richard D KolodnerLudwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, CA 92093-0669; rkolodner@ucsd.edu.ORCID 0000-0002-4806-8384
University of California San Diego · USInstituto Federal do Rio Grande do Norte · BR

Funding

ENZYMATIC MECHANISMS OF GENETIC RECOMBINATIONR01GM026017 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard D Kolodner · 1985 to 2026
$10.5M
NIGMS NIH HHS R01 GM026017
6 · The paper itself

Abstract

Gross Chromosomal Rearrangements (GCRs) play an important role in human diseases, including cancer. Although most of the nonessential Genome Instability Suppressing (GIS) genes in

Indexed as

Genes, SuppressorGenome, FungalGenomic InstabilityDNA DamageHumansMutationNeoplasmsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTumor Suppressor ProteinsSaccharomyces cerevisiae ProteinsTumor Suppressor Proteinscancerchromosome dynamics and replicationgenome instability

Identifiers

PMID31409704
PMCPMC6717276
OpenAlexW2969181388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.