ArticleJournal of cell science2019
Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.
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Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
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Who cites it
47 citing papers in PubMed.
- Screening of anti-metastasis drugs by targeting angiopellosis and cancer cluster extravasation.Science advances · 2026Article
- An injectable hydrogen-producing bacteria hydrogel for cardiac repair in rodent and porcine models.Nature biomedical engineering · 2026Article
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- Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells.Nature materials · 2026Article
- Endothelial dysfunction determines vascular mechanisms of metastatic progression in breast cancer.Discover oncology · 2026Review
- Microneedle Delivery of Small Extracellular Vesicles From Young Blood to Treat Endothelial Senescence.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Endothelial activation during the diapedesis of cancer cells: between the kiss of death and therapeutic breakthrough.Cellular & molecular biology letters · 2025Review
- Redefining cancer care: harnessing circulating tumor cells' potential for improved diagnosis and prognosis.Cancer cell international · 2025Review
- Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2/HO-1 pathway.Bioactive materials · 2025Article
- Exosomes from young plasma stimulate the osteogenic differentiation and prevent osteoporosis via miR-142-5p.Bioactive materials · 2025Article
- Inhalable Hsa-miR-30a-3p Liposomes Attenuate Pulmonary Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Harnessing exosomes for targeted drug delivery systems to combat brain cancer.Cancer cell international · 2025Review
- A Spatially Distributed Microneedle System for Bioorthogonal T Cell-Guided Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Liquid Biopsy for Cutaneous Melanoma: Opportunities and Challenges in Detecting and Characterizing Circulating Tumor Cells.Journal of dermato-oncology · 2025Article
- Decoding Metastasis: From Cell Death to Fusion in Cancer Progression.Current cancer drug targets · 2025Review
- The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability.PloS one · 2025Article
- Translational inhalable extracellular vesicle-based mRNA therapy for the treatment of lung cancer.Clinical and translational medicine · 2025Article
- Fast and efficient isolation of murine circulating tumor cells using screencell technology for pre-clinical analyzes.Scientific reports · 2024Article
- Systematic optimization and evaluation of culture conditions for the construction of circulating tumor cell clusters using breast cancer cell lines.BMC cancer · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Tyler A AllenDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0002-8729-6339
Dana AsadJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27607, USA.
Emmanuel AmuDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
M Taylor HensleyDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0002-7202-2116
Jhon CoresDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Adam VandergriffDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Junnan TangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, China.
Phuong-Uyen DinhDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Deliang ShenDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0002-1826-5141
Li QiaoDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0002-6372-7157
Teng SuJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27607, USA.
Shiqi HuDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Hongxia LiangDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0002-3229-1426
Heather ShiveDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Erin HarrellDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Connor CampbellDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Xinxia PengDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Jeffrey A YoderDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Ke ChengDepartment of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA kcheng3@ncsu.edu.
Funding
Targeted Nanoparticles for Stem Cell Redirecting and Regenerative MedicineR01HL123920 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CHENG, KE · 2015 to 2023
$4.8MEnhancing vascular delivery of stem cells and microparticlesR01HL137093 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CHENG, KE · 2017 to 2020
$1.5MIdentification of genetic collaborators in cancer with a brca2-mutant zebrafish modelK01OD021419 · OD · OHIO STATE UNIVERSITY · PI SHIVE, HEATHER R. · 2016 to 2021
$731kMulticellular Cancer Cell Cluster Extravasation through AngiopellosisF31CA217153 · NCI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI ALLEN, TYLER · 2017 to 2017
$31kNCI NIH HHS F31 CA217153NHLBI NIH HHS R01 HL123920NHLBI NIH HHS R01 HL137093NIH HHS K01 OD021419
Abstract
Metastasis accounts for the majority of all cancer deaths, yet the process remains poorly understood. A pivotal step in the metastasis process is the exiting of tumor cells from the circulation, a process known as extravasation. However, it is unclear how tumor cells extravasate and whether multicellular clusters of tumor cells possess the ability to exit as a whole or must first disassociate. In this study, we use
Indexed as
AnimalsCell CountCell MovementHeLa CellsHumansMiceNeoplasm MetastasisNeoplastic Cells, CirculatingAngiopellosisCancer exodus hypothesisCirculating tumor cell clusterMetastasisTumor cell extravasation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.