Evidence map›Paper›PMID 31409682›Full record

ArticlemBio2019

Pseudomonas aeruginosa Interstrain Dynamics and Selection of Hyperbiofilm Mutants during a Chronic Infection.

Erin S Gloag, Christopher W Marshall, Daniel Snyder, Gina R Lewin, Jacob S Harris, Alfonso Santos-Lopez, Sarah B Chaney, Marvin Whiteley, Vaughn S Cooper, Daniel J Wozniak

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 66 citations in OpenAlex.

  1. Journal of bacteriology · 2026
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  2. Genetic diversification ofApplied and environmental microbiology · 2026
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  4. A Novel Method to Monitor the Evolution of Antimicrobial Resistance inInternational journal of molecular sciences · 2026
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  7. bioRxiv : the preprint server for biology · 2025
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  12. Mutation ofMicrobiology spectrum · 2024
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  13. Review
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  15. The non-attached biofilm aggregate.Communications biology · 2023
    Review
  16. Article
  17. Article
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  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Erin S Gloag *Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Christopher W Marshall *Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Daniel SnyderDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Gina R LewinSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA.
Jacob S HarrisDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Alfonso Santos-LopezDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Sarah B ChaneyDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Marvin WhiteleySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA.
Vaughn S CooperDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7726-0765
Daniel J WozniakDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA Daniel.Wozniak@osumc.edu.
The Ohio State University · USUniversity of Pittsburgh · USGeorgia Institute of Technology · US

Funding

Predicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2M
The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
The impact of bacteriophage therapy on wound infection dynamicsR01AI169865 · NIAID · OHIO STATE UNIVERSITY · PI Daniel J Wozniak · 2022 to 2026
$3.7M
Revisiting alginate paradigmsR01AI134895 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2018 to 2022
$2.5M
The matrix of Pseudomonas aeruginosa biofilmsR01AI061396 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WOZNIAK, DANIEL J · 2005 to 2009
$2.1M
Pseudomonas biofilms and immunityR01AI097511 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2013 to 2017
$1.9M
Molecular mechanisms of adaptive diversity in Burkholderia biofilmsR01GM110444 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, VAUGHN · 2015 to 2019
$1.5M
NIAID NIH HHS R01 AI061396NIAID NIH HHS R01 AI077628NIAID NIH HHS R01 AI097511NIAID NIH HHS R01 AI134895NIAID NIH HHS R01 AI169865NIAID NIH HHS U01 AI124302NIGMS NIH HHS R01 GM110444
6 · The paper itself

Abstract

Opportunistic pathogens establishing new infections experience strong selection to adapt, often favoring mutants that persist. Capturing this initial dynamic is critical for identifying the first adaptations that drive pathogenesis. Here we used a porcine full-thickness burn wound model of chronic infection to study the evolutionary dynamics of diverse

Indexed as

AnimalsBacterial ProteinsBacteriophagesBiofilmsBiological EvolutionCRISPR-Associated ProteinsCyclic GMPGenetic FitnessGenome, BacterialMutationPhenotypePseudomonas aeruginosaPseudomonas InfectionsSwineWound InfectionBacterial ProteinsCRISPR-Associated ProteinsCyclic GMPbacteriophagesbiofilmschronic infectionCRISPR-Cascyclic di-GMPevolutionexopolysaccharidePseudomonas aeruginosaRSCVWsp

Identifiers

PMID31409682
PMCPMC6692513
OpenAlexW2968902403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.