Evidence map›Paper›PMID 31409621›Full record

ArticleMolecular pharmacology2019

Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2.

Xiao Shi, Tracy L Swanson, Nicholas B Miner, Amy J Eshleman, Aaron Janowsky

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiao ShiResearch Service, Veterans Affairs Portland Health Care System, Portland, Oregon (X.S., T.L.S., N.B.M., A.J.E., A.J.); and The Methamphetamine Abuse Research Center (X.S., A.J.) and Departments of Psychiatry (X.S., T.L.S., A.J.E., A.J.) and Behavioral Neuroscience (N.B.M., A.J.E., A.J.), Oregon Health and Science University, Portland, Oregon.
Tracy L SwansonResearch Service, Veterans Affairs Portland Health Care System, Portland, Oregon (X.S., T.L.S., N.B.M., A.J.E., A.J.); and The Methamphetamine Abuse Research Center (X.S., A.J.) and Departments of Psychiatry (X.S., T.L.S., A.J.E., A.J.) and Behavioral Neuroscience (N.B.M., A.J.E., A.J.), Oregon Health and Science University, Portland, Oregon.
Nicholas B MinerResearch Service, Veterans Affairs Portland Health Care System, Portland, Oregon (X.S., T.L.S., N.B.M., A.J.E., A.J.); and The Methamphetamine Abuse Research Center (X.S., A.J.) and Departments of Psychiatry (X.S., T.L.S., A.J.E., A.J.) and Behavioral Neuroscience (N.B.M., A.J.E., A.J.), Oregon Health and Science University, Portland, Oregon.
Amy J EshlemanResearch Service, Veterans Affairs Portland Health Care System, Portland, Oregon (X.S., T.L.S., N.B.M., A.J.E., A.J.); and The Methamphetamine Abuse Research Center (X.S., A.J.) and Departments of Psychiatry (X.S., T.L.S., A.J.E., A.J.) and Behavioral Neuroscience (N.B.M., A.J.E., A.J.), Oregon Health and Science University, Portland, Oregon.
Aaron JanowskyResearch Service, Veterans Affairs Portland Health Care System, Portland, Oregon (X.S., T.L.S., N.B.M., A.J.E., A.J.); and The Methamphetamine Abuse Research Center (X.S., A.J.) and Departments of Psychiatry (X.S., T.L.S., A.J.E., A.J.) and Behavioral Neuroscience (N.B.M., A.J.E., A.J.), Oregon Health and Science University, Portland, Oregon janowsky@ohsu.edu.
Oregon Health & Science University · USVA Portland Health Care System · US

Funding

Traditional Service Core [Translational Service Core (TSC)]P50DA018165 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2006 to 2016
$13.0M
BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
Opioid Sensitive GABA inputs to the Ventral MidbrainR01DA034388 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 2012 to 2016
$967k
Trace amine receptor-mediated methamphetamine response in brainI01BX002758 · VA · PORTLAND VA MEDICAL CENTER · PI JANOWSKY, AARON J. · 2016 to 2019
–
BLRD VA I01 BX002758NIDA NIH HHS P50 DA018165NIDA NIH HHS R01 DA034388NIDA NIH HHS T32 DA007262
6 · The paper itself

Abstract

Methamphetamine (MA) is highly addictive and neurotoxic, causing cell death in humans and in rodent models. MA, along with many of its analogs, is an agonist at the G protein-coupled trace amine-associated receptor 1 (TAAR1). TAAR1 activation protects against MA-induced degeneration of dopaminergic neurons, suggesting that TAAR1 plays a role in regulating MA-induced neurotoxicity. However, the mechanisms involved in TAAR1's role in neurotoxicity and cell death have not been described in detail. In this study, we investigated the apoptosis pathway in

Indexed as

AnimalsCell SurvivalGene Expression RegulationGene Knockout TechniquesHEK293 CellsHumansMAP Kinase Signaling SystemMesencephalonMethamphetamineMiceNeuronsOxazolesPhenethylaminesPhosphorylationProto-Oncogene Proteins c-bcl-2Receptors, G-Protein-CoupledBCL2 protein, humanMethamphetamineOxazolesPhenethylaminesProto-Oncogene Proteins c-bcl-2Receptors, G-Protein-CoupledRO5166017Trace Amine-Associated Receptors

Identifiers

PMID31409621
PMCPMC6744391
OpenAlexW2967862271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.