ArticleBMC health services research2019
Health-resource use and quality of life in children with bronchiectasis: a multi-center pilot cohort study.
Article in BMC health services research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04765033 (Efficacy of Nebulised 5% Hypertonic Saline in Children With Chronic Suppurative Lung Disease), which is not on this map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Nebulised 5% Hypertonic Saline in Children With Chronic Suppurative Lung Disease
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Health-related quality of life and associated factors in children with bronchiectasis: A systematic review.European journal of pediatrics · 2026Pooled it
- Mucolytics for children with chronic suppurative lung disease.The Cochrane database of systematic reviews · 2025Pooled it
- Quality of life assessment tools for chronic cough in children: a systematic review.Frontiers in public health · 2025Pooled it
- A systematic literature review of the clinical and socioeconomic burden of bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Long-term macrolide treatment for non-cystic fibrosis bronchiectasis in children: a meta-analysis.Scientific reports · 2021Pooled it
- Treatable traits in paediatric bronchiectasis: current practice and a proposed checklist.European journal of pediatrics · 2026Article
- Global, regional, and national burden of respiratory diseases and attributable risk factors in adolescents and young adults, 1990-2021: a Global Burden of Disease 2021 analysis.Archives of medical science : AMS · 2026Article
- Pediatric bronchiectasis-the importance of early diagnosis of children across the chronic wet cough spectrum.Journal of thoracic disease · 2025Review
- Article
- Rasch validation of the short form (8 item) PC-QoL questionnaire and applicability of use as a health state classification system for a new preference-based measure.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Erdosteine in children and adults with bronchiectasis (BETTER trial): study protocol for a multicentre, double-blind, randomised controlled trial.BMJ open respiratory research · 2024Article
- Clinical determinants for State-Trait Anxiety Inventory of the parents of children with respiratory problems.Pediatric pulmonology · 2024Article
- Health-related quality of life measures used with Indigenous children/youth in the Pacific Rim: a scoping review.BMJ open · 2023Article
- Gastrointestinal factors associated with risk of bronchiectasis in children.Pediatric pulmonology · 2023Article
- Quality standards for managing children and adolescents with bronchiectasis: an international consensus.Breathe (Sheffield, England) · 2022Review
- Reducing exacerbations in children and adults with primary ciliary dyskinesia using erdosteine and/or azithromycin therapy (REPEAT trial): study protocol for a multicentre, double-blind, double-dummy, 2×2 partial factorial, randomised controlled trial.BMJ open respiratory research · 2022Article
- Bronchiectasis in African children: Challenges and barriers to care.Frontiers in pediatrics · 2022Review
- Barriers and facilitators of physical activity in children with bronchiectasis: Perspectives from children and parents.Frontiers in pediatrics · 2022Article
- Utility of a personalisedBMJ open · 2021Article
- Burden of Care for Children with Bronchiectasis from Parents/Carers Perspective.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundBronchiectasis in children is an important, but under-researched, chronic pulmonary disorder that has negative impacts on health-related quality of life. Despite this, it does not receive the same attention as other chronic pulmonary conditions in children such as cystic fibrosis. We measured health resource use and health-related quality of life over a 12-month period in children with bronchiectasis.
methodsWe undertook a prospective cohort study of 85 children aged < 18-years with high-resolution chest computed-tomography confirmed bronchiectasis undergoing management in three pediatric respiratory medical clinics in Darwin and Brisbane, Australia and Auckland, New Zealand. Children with cystic fibrosis or receiving cancer treatment were excluded. Data collected included the frequency of healthcare attendances (general practice, specialists, hospital and/or emergency departments, and other), medication use, work and school/childcare absences for parents/carers and children respectively, and both parent/carer and child reported quality of life and cough severity.
resultsOverall, 951 child-months of observation were completed for 85 children (median age 8.7-years, interquartile range 5.4-11.3). The mean (standard deviation) number of exacerbations was 3.3 (2.2) per child-year. Thirty of 264 (11.4%) exacerbation episodes required hospitalization. Healthcare attendance and antibiotic use rates were high (30 and 50 per 100 child-months of observation respectively). A carer took leave from work for 53/236 (22.5%) routine clinic visits. Absences from school/childcare due to bronchiectasis were 24.9 children per 100 child-months. Quality of life scores for both the parent/carer and child were highly-correlated with one another, remained stable over time and were negatively associated with cough severity.
conclusionsHealth resource use in this cohort of children is high, reflecting their severe disease burden. Studies are now needed to quantify the direct and societal costs of disease and to evaluate interventions that may reduce disease burden, particularly hospitalizations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.