Observational studyBMC pulmonary medicine2019
Hyperbaric oxygen therapy effects on pulmonary functions: a prospective cohort study.
Observational study in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03754985 (Hyperbaric Oxygen Therapy Effects on Pulmonary Functions), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hyperbaric Oxygen Therapy Effects on Pulmonary Functions
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Liberal or conservative oxygen therapy for ventilated patients in the ICU: a meta-analysis of randomized controlled trials.Journal of cardiothoracic surgery · 2021Pooled it
- The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review.European journal of medical research · 2021Pooled it
- Trial
- A study on the effect of acute hyperbaric oxygen intervention on aerobic endurance.Journal of physiological anthropology · 2025Trial
- The Adjunctive Role of Hyperbaric Oxygen Therapy in Microbial Infection-Related Conditions.International journal of medical sciences · 2026Review
- Exploring Oxygen Therapy as a Supporting Treatment for Asthma: Current Insights and Perspectives.International journal of molecular sciences · 2025Review
- Impact of Host and Bacterial Metabolism on Antibiotic Susceptibility.Biochemistry · 2025Review
- Article
- Single-Cell Transcriptomics Reveals Stem Cell-Derived Exosomes Attenuate Inflammatory Gene Expression in Pulmonary Oxygen Toxicity.International journal of molecular sciences · 2025Article
- Translational medicine for acute lung injury.Journal of translational medicine · 2024Review
- Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis.Genes & diseases · 2023Article
- Protocol of HOTFy: randomised clinical trial to hyperbaric oxygen therapy in fibromyalgia.BMJ open · 2023Article
- Pulmonary function following hyperbaric oxygen therapy: A longitudinal observational study.PloS one · 2023Observational
- Article
- Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics.Redox biology · 2022Review
- Volatile Organic Compounds Frequently Identified after Hyperbaric Hyperoxic Exposure: The VAPOR Library.Metabolites · 2022Article
- Hyperbaric oxygen treatment for long coronavirus disease-19: a case report.Journal of medical case reports · 2022Article
- Potential Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective Endocarditis.Frontiers in cellular and infection microbiology · 2022Review
- A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities.Medicina (Kaunas, Lithuania) · 2021Review
- The Role of Hyperbaric Oxygen Treatment for COVID-19: A Review.Advances in experimental medicine and biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxygen toxicity is one potential side effect of hyperbaric oxygen therapy (HBOT). Previous small studies showed mild reductions in pulmonary functions reflecting reductions in small airway conductance after repetitive hyperbaric oxygen sessions. However, there are no updated data with well performed pulmonary tests that address the pulmonary effect of the currently used HBOT protocols. The aim of this study was to evaluate the effect of HBOT on pulmonary functions of patients receiving the currently used HBOT protocol.
methodsProspective analysis included patients, 18 years or older, scheduled for 60 daily HBOT sessions between 2016 and 2018. Each session was 90 min of 100% oxygen at 2 ATA with 5 min air breaks every 20 min, 5 days per week. Pulmonary functions, measured at baseline and after HBOT, included forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1) and peak expiratory flow rate (PEF).
resultsThe mean age was 60.36 ± 15.43 and 62.5% (55/88) were males. Most of the patients (83/88, 94.3%) did not have any pulmonary disease prior to inclusion and 30.7% (27/88) had a history of smoking. Compared to baseline values, at the completion of 60 HBOT sessions, there were no significant changes in FEV1 (0.163), FEV1/FVC ratio (0.953) and FEF25-75% (0.423). There was a statistically significant increase though not clinically relevant increase in FVC (0.1 ± 0.38 l) and PEF (0.5 ± 1.4 l) with a 0.014 and 0.001 respectively.
conclusionRegarding pulmonary functions, repeated hyperbaric oxygen exposure based on the currently used HBOT protocol is safe. Surprisingly, there was a modest non clinically significant though statistically significant improvement in PEF and FVC in the current cohort of patients who were without chronic lung diseases.
trial registrationClinicaltrials.gov, trial ID: NCT03754985 , (Nov 2018) Retrospectively registered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.