ArticleJournal of orthopaedic surgery and research2019
Viscoelasticity and histology of the human cartilage in healthy and degenerated conditions of the knee.
Article in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Development and tribological characterization of polyvinyl alcohol-based artificial cartilage forFrontiers in bioengineering and biotechnology · 2026Article
- Assessment of morphology, radiopacity gradient and mechanical properties of articular cartilage with contrast-enhanced high-resolution peripheral quantitative computed tomography.Frontiers in bioengineering and biotechnology · 2026Article
- Chitosan/Platelet-Rich Plasma Implants in an Ovine Arthroscopic Model of Meniscus Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Raman spectroscopic probe provides optical biomarkers of cartilage composition predictive of tissue function.Osteoarthritis and cartilage · 2025Article
- Synthetic 3D printed tibial plateau with gradient material properties for biomechanical accuracy.Frontiers in bioengineering and biotechnology · 2025Article
- Modular iodinated carboxybetaine copolymers as charge-sensitive contrast agents for the detection of cartilage degradation.Materials today. Bio · 2024Article
- Cartilage Integrity: A Review of Mechanical and Frictional Properties and Repair Approaches in Osteoarthritis.Healthcare (Basel, Switzerland) · 2024Review
- Mechanical and histological properties of native medial menisci compared to allograph medial menisci in the osteoarthritic knee.Frontiers in bioengineering and biotechnology · 2024Article
- Bioinformatics identification and integrative analysis of ferroptosis-related key lncRNAs in patients with osteoarthritis.Bioscience reports · 2023Article
- Intraoperative Acoustic Evaluation of Living Human Knee Cartilage-Comparison with Respect to Cartilage Degeneration and Aging.Cartilage · 2023Article
- Relations between Structure/Composition and Mechanics in Osteoarthritic Regenerated Articular Tissue: A Machine Learning Approach.International journal of molecular sciences · 2023Article
- Article
- Optimization of In Situ Indentation Protocol to Map the Mechanical Properties of Articular Cartilage.Materials (Basel, Switzerland) · 2022Article
- Article
- Osteoarthritis-Related Degeneration Alters the Biomechanical Properties of Human Menisci Before the Articular Cartilage.Frontiers in bioengineering and biotechnology · 2021Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are many studies on osteoarthritis, but only a few studies deal with human arthrosis, comparing the mechanical properties of healthy and diseased samples. In most of these studies, only isolated areas of the tibia are examined. There is currently only one study investigating the complete mapping of cartilage tissue but not the difference between instantaneous modulus (IM) in healthy and diseased samples. The aim of this study is to investigate the relationship between the biomechanical and histological changes of articular cartilage in the pathogenesis of osteoarthritis.
methodsThe study compared 25 tibiae with medial gonarthrosis and 13 healthy controls. The IM was determined by automated indentation mapping using a Mach-1 V500css testing machine. A grid was projected over the sample and stored so that all measurements could be taken at the same positions (100 ± 29 positions across the tibiae). This grid was then used to perform the thickness measurement using the needle method. Samples were then taken for histological examinations using a hollow milling machine. Then Giemsa and Safranin O staining were performed. In order to determine the degree of arthrosis according to histological criteria, the assessment was made with regard to Osteoarthritis Research Society International (OARSI) and AHO scores.
resultsA significant difference (p < 0.05) could be observed in the measured IM between the controls with 3.43 ± 0.36 MPa and the samples with 2.09 ± 0.18 MPa. In addition, there was a significant difference in IM in terms of meniscus-covered and meniscus-uncovered areas. The difference in cartilage thickness between 2.25 ± 0.11 mm controls and 2.0 ± 0.07 mm samples was highly significant with p < 0.001. With regard to the OARSI and AHO scores, the samples differed significantly from the controls. The OARSI and AHO scores showed a significant difference between meniscus-covered and meniscus-uncovered areas.
conclusionsThe controls showed significantly better viscoelastic behavior than the arthrotic samples in the measured IM. The measured biomechanical values showed a direct correlation between histological changes and altered biomechanics in gonarthrosis.
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