Evidence map›Paper›PMID 31409326›Full record

ArticleBMC pulmonary medicine2019

Aerosol therapy in relation to retinopathy of prematurity in mechanically ventilated preterm infants.

Mei-Chin Yang, Hsiu-Feng Hsiao, Hsiu-Li Tseng, Ya-Wen Chiu, Yi-Hao Weng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mei-Chin YangDepartment of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Hsiu-Feng HsiaoDepartment of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Hsiu-Li TsengDepartment of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Ya-Wen ChiuMaster Program in Global Health and Development, College of Public Health, Taipei Medical University, Taipei, Taiwan.
Yi-Hao WengDepartment of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan. yihaoweng@cgmh.org.tw.ORCID http://orcid.org/0000-0002-6955-8593
Chang Gung University · TWTaipei Medical University · TW

Funding

Chang Gung Memorial Hospital, Linkou CMRPG1F0182Ministry of Science and Technology, Taiwan MOST 105-2410-H-038-011-SSSMinistry of Science and Technology, Taiwan MOST 106-2314-B-182A-032-
6 · The paper itself

Abstract

backgroundAerosol administration is increasingly being used as a therapeutic intervention for mechanically ventilated preterm infants. However, the effects of inhalation therapy on retinopathy of prematurity (ROP) have not yet been explored.

methodsA retrospective cohort study was conducted in a tertiary level neonatal intensive care unit (NICU) from 2011 to 2013. All preterm infants with a gestational age (GA) of 24~29 weeks receiving invasive intubation for more than 1 week in the NICU were included. Infants with severe congenital anomalies were excluded. ROP was defined as stage II or greater according to medical records by ophthalmologists. A multivariate logistic regression model was used to estimate the risk of ROP in relation to inhalation therapy after adjusting for confounders.

resultsIn total, 205 infants were enrolled in this study, including 154 with inhalation therapy and 51 without inhalation therapy. Univariate analyses showed an association of inhalation with the following characteristics: sex (p = 0.047), GA (p = 0.029), sepsis (p = 0.047), bronchopulmonary dysplasia (BPD) (p < 0.001), and ROP (p = 0.001). Furthermore, logistic regression analysis indicated that inhalation therapy was an independent risk factor for ROP (odds ratio (OR) = 2.639; 95% confidence interval (CI) = 1.050~6.615). In addition, infants with a GA of 24~25 weeks (OR = 6.063; 95% CI = 2.482~14.81) and 26~27 weeks (OR = 3.825; 95% CI = 1.694~8.638) were at higher risk of ROP than those with a GA of 28~29 weeks. Other factors - including sex, sepsis, BPD, and delivery mode - did not carry significant risk.

conclusionAerosol therapy with pure oxygen delivery is associated with ROP. Clinicians should exercise great caution when conducting aerosol therapy with excess oxygen in mechanically ventilated preterm infants.

Indexed as

Infant, PrematureBirth WeightBronchopulmonary DysplasiaFemaleGestational AgeHumansInfant, NewbornIntensive Care Units, NeonatalLogistic ModelsMaleMultivariate AnalysisOxygen Inhalation TherapyRespiration, ArtificialRetinopathy of PrematurityRetrospective StudiesRisk FactorsAerosol therapyGAHFViNOROP

Identifiers

PMID31409326
PMCPMC6693186
OpenAlexW2968456702

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.