ArticleJournal of the Royal Society, Interface2019
Anomalous water dynamics in brain: a combined diffusion magnetic resonance imaging and neutron scattering investigation.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Diffusion MRI experimental design optimization for microstructure imaging.Communications biology · 2026Article
- Quasi-elastic neutron scattering studies on bacterial spores and their hydration water.Scientific reports · 2026Article
- Cellular dynamics as a marker of normal-to-cancer transition in human cells.Scientific reports · 2023Article
- Imaging crossing fibers in mouse, pig, monkey, and human brain using small-angle X-ray scattering.Acta biomaterialia · 2023Article
- Sub-Nanosecond Dynamics of Pathologically Relevant Bio-Macromolecules Observed by Incoherent Neutron Scattering.Life (Basel, Switzerland) · 2022Review
- Water Dynamics in Cancer Cells: Lessons from Quasielastic Neutron Scattering.Medicina (Kaunas, Lithuania) · 2022Review
- Distribution and orientation of nerve fibers and myelin assembly in a brain section retrieved by small-angle neutron scattering.Scientific reports · 2021Article
- The molecular dynamics of bacterial spore and the role of calcium dipicolinate in core properties at the sub-nanosecond time-scale.Scientific reports · 2020Article
- Brain lateralization probed by water diffusion at the atomic to micrometric scale.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water diffusion is an optimal tool for investigating the architecture of brain tissue on which modern medical diagnostic imaging techniques rely. However, intrinsic tissue heterogeneity causes systematic deviations from pure free-water diffusion behaviour. To date, numerous theoretical and empirical approaches have been proposed to explain the non-Gaussian profile of this process. The aim of this work is to shed light on the physics piloting water diffusion in brain tissue at the micrometre-to-atomic scale. Combined diffusion magnetic resonance imaging and first pioneering neutron scattering experiments on bovine brain tissue have been performed in order to probe diffusion distances up to macromolecular separation. The coexistence of free-like and confined water populations in brain tissue extracted from a bovine right hemisphere has been revealed at the micrometre and atomic scale. The results are relevant for improving the modelling of the physics driving intra- and extracellular water diffusion in brain, with evident benefit for the diffusion magnetic resonance imaging technique, nowadays widely used to diagnose, at the micrometre scale, brain diseases such as ischemia and tumours.
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