ArticleJournal of the Royal Society, Interface2019
The impact of balloon-expandable transcatheter aortic valve replacement on concomitant mitral regurgitation: a comprehensive computational analysis.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Manufacturing 3D aortic root models for in vitro assessment of calcific aortic valve stenosis.Annals of biomedical engineering · 2026Article
- The effect of balloon-expandable stent and self-expanding stent on changes in mitral annular motion after aortic valve replacement in patients with aortic stenosis.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024Article
- Patient-Specific Heart Geometry Modeling for Solid Biomechanics Using Deep Learning.IEEE transactions on medical imaging · 2024Article
- Echocardiographic Evaluation after Transcatheter Aortic Valve Implantation: A Comprehensive Review.Life (Basel, Switzerland) · 2023Review
- Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022Review
- The Technological Basis of a Balloon-Expandable TAVR System: Non-occlusive Deployment, Anchorage in the Absence of Calcification and Polymer Leaflets.Frontiers in cardiovascular medicine · 2022Article
- Fluid-Structure Interaction Analyses of Biological Systems Using Smoothed-Particle Hydrodynamics.Biology · 2021Review
- Biomechanical Identification of High-Risk Patients Requiring Permanent Pacemaker After Transcatheter Aortic Valve Replacement.Frontiers in bioengineering and biotechnology · 2021Article
- Computer simulations of transapical mitral valve repair with neochordae implantation: Clinical implications.JTCVS open · 2020Article
- Comparative quantification of primary mitral regurgitation by computer modeling and simulated echocardiography.American journal of physiology. Heart and circulatory physiology · 2020Article
- The Impact of Self-Expandable Transcatheter Aortic Valve Replacement on Concomitant Functional Mitral Regurgitation: A Comprehensive Engineering Analysis.Structural heart : the journal of the Heart Team · 2020Article
- A Comprehensive Engineering Analysis of Left Heart Dynamics After MitraClip in a Functional Mitral Regurgitation Patient.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The aortic and mitral valves function in a reciprocal interdependent fashion. However, the impact of transcatheter aortic valve replacement (TAVR) on the aortic-mitral continuity and severity of mitral regurgitation (MR) are poorly understood. In this study, a comprehensive engineering analysis was performed to investigate the impact of TAVR on MR severity and left heart dynamics in a retrospective patient case who harbours bicuspid aortic valve stenosis and concomitant functional MR. The TAVR procedure was computer simulated using a balloon-expandable valve, and the impact of three implantation heights on aortic-mitral coupling, MR severity and device performance were analysed. The accuracy and predictability of the computer modelling framework were validated with pre- and post-operative echo data. The highest deployment model resulted in higher stresses in the native leaflets, contact radial force and stent recoil, while the midway implantation model gave better haemodynamic performance and MR reduction in this patient case. Although the regurgitant volume decreased (less than 10%) for the three deployment configurations, no significant differences in MR severity improvement and mitral leaflet tethering were found. Acute improvement in MR was (i) due to the mechanical compression of the stent against the aortic-mitral curtain, (ii) due to an immediate drop in the ventricular pressure and transmitral pressure gradient. Albeit a single real clinical case, it is our hope that such detailed engineering computational analysis could shed light on the underlying biomechanical mechanisms of TAVR impact on MR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.