ArticleJournal of the Royal Society, Interface2019
Mathematical modelling of the restenosis process after stent implantation.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Molecular profiling of coronary stent testenosis: A systematic review and functional analysis of implicated genes.Medicine · 2026Pooled it
- A Comprehensive Numerical Simulation on the Safety and Efficacy of Circular-Versus Trapezoidal-Shaped Intravascular Drug-Eluting Stents.International journal for numerical methods in biomedical engineering · 2026Article
- A computational model of coronary arteries with in-stent restenosis coupling hemodynamics and pharmacokinetics with growth mechanics.Scientific reports · 2025Article
- Patient-specific coronary angioplasty simulations - A mixed-dimensional finite element modeling approach.Computers in biology and medicine · 2025Article
- Fully coupled hybrid in-silico modeling of atherosclerosis: A multi-scale framework integrating CFD, transport phenomena and agent-based modeling.Frontiers in bioengineering and biotechnology · 2025Article
- A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics.Journal of the Royal Society, Interface · 2022Article
- Effect of Rivaroxaban and Clopidogrel Combination Therapy on In-Stent Responses After Everolimus-Eluting Stent Implantation in a Porcine Coronary Model.Journal of atherosclerosis and thrombosis · 2022Article
- Computational model of damage-induced growth in soft biological tissues considering the mechanobiology of healing.Biomechanics and modeling in mechanobiology · 2021Article
- A homogenized constrained mixture model of restenosis and vascular remodelling after balloon angioplasty.Journal of the Royal Society, Interface · 2021Article
- Multiscale Computational Modeling of Vascular Adaptation: A Systems Biology Approach Using Agent-Based Models.Frontiers in bioengineering and biotechnology · 2021Review
- Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress.Frontiers in physiology · 2021Article
- [Review of studies on the biomechanical modelling of the coupling effect between stent degradation and blood vessel remodeling].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Mechanistic evaluation of long-term in-stent restenosis based on models of tissue damage and growth.Biomechanics and modeling in mechanobiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stenting procedure has evolved to become a highly successful technique for the clinical treatment of advanced atherosclerotic lesions in arteries. However, the development of in-stent restenosis remains a key problem. In this work, a novel two-dimensional continuum mathematical model is proposed to describe the complex restenosis process following the insertion of a stent into a coronary artery. The biological species considered to play a key role in restenosis development are growth factors, matrix metalloproteinases, extracellular matrix, smooth muscle cells and endothelial cells. Diffusion-reaction equations are used for modelling the mass balance between species in the arterial wall. Experimental data from the literature have been used in order to estimate model parameters. Moreover, a sensitivity analysis has been performed to study the impact of varying the parameters of the model on the evolution of the biological species. The results demonstrate that this computational model qualitatively captures the key characteristics of the lesion growth and the healing process within an artery subjected to non-physiological mechanical forces. Our results suggest that the arterial wall response is driven by the damage area, smooth muscle cell proliferation and the collagen turnover among other factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.