Evidence map›Paper›PMID 31409111›Full record

ArticleCell transplantation2019

Progenitor/Stem Cell Delivery by Suprarenal Aorta Route in Acute Kidney Injury.

Érika B Rangel, Samirah A Gomes, Rosemeire Kanashiro-Takeuchi, Joshua M Hare

Open access · goldAbstract read
In one paragraph

Article in Cell transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Érika B RangelInterdisciplinary Stem Cell Institute, Leonard M Miller School of Medicine, University of Miami, USA.ORCID 0000-0003-0982-2484
Samirah A GomesInterdisciplinary Stem Cell Institute, Leonard M Miller School of Medicine, University of Miami, USA.
Rosemeire Kanashiro-TakeuchiInterdisciplinary Stem Cell Institute, Leonard M Miller School of Medicine, University of Miami, USA.
Joshua M HareInterdisciplinary Stem Cell Institute, Leonard M Miller School of Medicine, University of Miami, USA.
University of Miami · US

Funding

Cardioprotective Effect of Growth Hormone Releasing HormoneR01HL107110 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARE, JOSHUA M · 2011 to 2020
$5.9M
Aging impairs stem-cell mediated myocardial repairR01AG025017 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARE, JOSHUA M · 2004 to 2008
$1.5M
NHLBI NIH HHS R01 HL107110NIA NIH HHS R01 AG025017
6 · The paper itself

Abstract

Progenitor/stem cell-based kidney regenerative strategies are a key step towards the development of novel therapeutic regimens for kidney disease treatment. However, the route of cell delivery, e.g., intravenous, intra-arterial, or intra-parenchymal, may affect the efficiency for kidney repair in different models of acute and chronic injury. Here, we describe a protocol of intra-aorta progenitor/stem cell injection in rats following either acute ischemia-reperfusion injury or acute proteinuria induced by puromycin aminonucleoside (PAN) - the experimental prototype of human minimal change disease and early stages of focal and segmental glomerulosclerosis. Vascular clips were applied across both renal pedicles for 35 min, or a single dose of PAN was injected via intra-peritoneal route, respectively. Subsequently, 2 x 10

Indexed as

Acute DiseaseAcute Kidney InjuryAnimalsFemaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationProteinuriaPuromycin AminonucleosideRatsRegenerationRenal ArteryReperfusion InjuryVascular Surgical ProceduresWorkflowPuromycin Aminonucleosideacute kidney injuryacute proteinuriaengraftmentischemia-reperfusion injuryprogenitor/stem cellssurgical technique

Identifiers

PMID31409111
PMCPMC6802150
OpenAlexW2968276544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.