Evidence map›Paper›PMID 31409048›Full record

ReviewJournal of clinical medicine2019

What Pediatricians Should Know Before Studying Gut Microbiota.

Lorenzo Drago, Simona Panelli, Claudio Bandi, Gianvincenzo Zuccotti, Matteo Perini, Enza D'Auria

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. A Journey on the Skin Microbiome: Pitfalls and Opportunities.International journal of molecular sciences · 2021
    Review
  6. Review
  7. Journal of clinical medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lorenzo DragoDepartment of Biomedical Sciences for Health, Università di Milano, 20133 Milan, Italy. lorenzo.drago@unimi.it.
Simona PanelliDepartment of Biomedical and Clinical Sciences "L. Sacco", Pediatric Clinical Research Center "Invernizzi", Università di Milano, 20157 Milan, Italy.
Claudio BandiDepartment of Biomedical and Clinical Sciences "L. Sacco", Pediatric Clinical Research Center "Invernizzi", Università di Milano, 20157 Milan, Italy.
Gianvincenzo ZuccottiDepartment of Pediatrics, Children's Hospital Vittore Buzzi, Università di Milan, 20141 Milan, Italy.
Matteo PeriniDepartment of Biomedical and Clinical Sciences "L. Sacco", Pediatric Clinical Research Center "Invernizzi", Università di Milano, 20157 Milan, Italy.
Enza D'AuriaDepartment of Pediatrics, Children's Hospital Vittore Buzzi, Università di Milan, 20141 Milan, Italy.
University of Milan · ITOspedale dei Bambini Vittore Buzzi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Billions of microorganisms, or "microbiota", inhabit the gut and affect its homeostasis, influencing, and sometimes causing if altered, a multitude of diseases. The genomes of the microbes that form the gut ecosystem should be summed to the human genome to form the hologenome due to their influence on human physiology; hence the term "microbiome" is commonly used to refer to the genetic make-up and gene-gene interactions of microbes. This review attempts to provide insight into this recently discovered vital organ of the human body, which has yet to be fully explored. We herein discuss the rhythm and shaping of the microbiome at birth and during the first years leading up to adolescence. Furthermore, important issues to consider for conducting a reliable microbiome study including study design, inclusion/exclusion criteria, sample collection, storage, and variability of different sampling methods as well as the basic terminology of molecular approaches, data analysis, and clinical interpretation of results are addressed. This basic knowledge aims to provide the pediatricians with a key tool to avoid data dispersion and pitfalls during child microbiota study.

Indexed as

childdysbiosisgut microbiotamaternal–fetal interfacemicrobiomenewbornpediatric disease

Identifiers

PMID31409048
PMCPMC6723848
OpenAlexW2967451417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.