Evidence map›Paper›PMID 31408804›Full record

ArticleJournal of critical care2019

Hemodynamic decompensation in normotensive patients admitted to the ICU with pulmonary embolism.

Het Patel, Jenny A Shih, Ryan Gardner, Parth V Patel, Catherine Ross, Margaret M Hayes, Ari Moskowitz, Michael W Donnino

Open access · greenAbstract read
In one paragraph

Article in Journal of critical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Het PatelDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States. Electronic address: hpatel12@bidmc.harvard.edu.
Jenny A ShihDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States. Electronic address: jshih2@bidmc.harvard.edu.
Ryan GardnerDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States. Electronic address: rmgardne@bidmc.harvard.edu.
Parth V PatelDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States. Electronic address: pvpatel@bidmc.harvard.edu.
Catherine RossDivision of Medical Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, MA, United States. Electronic address: catherine.ross@childrens.harvard.edu.
Margaret M HayesDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States. Electronic address: mhayes7@bidmc.harvard.edu.
Ari MoskowitzDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States. Electronic address: amoskowi@bidmc.harvard.edu.
Michael W DonninoDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States. Electronic address: mdonnino@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USBoston Children's Hospital · US

Funding

Thiamine as a Renal Protective Agent in Septic ShockK23GM128005 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MOSKOWITZ, ARI · 2018 to 2021
$761k
NIGMS NIH HHS K23 GM128005
6 · The paper itself

Abstract

purposeMany normotensive patients with acute pulmonary embolism (PE) are admitted to an intensive care unit (ICU) to monitor for hemodynamic decompensation. We investigated the incidence and causes of early hemodynamic decompensation in normotensive patients admitted to an ICU with PE. MATERIALS AND

methodsThis was a single-center, retrospective study of normotensive patients admitted to an ICU with primary diagnosis of PE between 2010 and 2017. The primary outcome was hemodynamic decompensation, defined as need for vasopressors within 48 h of ICU admission.

resultsOf 293 patients included in the study, hemodynamic decompensation occurred in 8 patients (2.7%). The two most common precipitants of hemodynamic decompensation were acute hemorrhage and PE-related right ventricular dysfunction - each contributing to hemodynamic decompensation in 3 patients.

conclusionsAmong patients admitted to the ICU with acute normotensive PE, early hemodynamic decompensation was rare. In patients who experienced decompensation, major bleeding and thrombotic complications were equally likely to have been the precipitant- highlighting the risks of diagnostic anchoring in this population. As our results suggest that ICU-level care may not be necessary for many of these patients, additional tools are needed to assist in the triage of normotensive patients with PE.

Indexed as

Intensive Care UnitsAgedFemaleHeart FailureHemodynamicsHumansMaleMiddle AgedMonitoring, PhysiologicPulmonary EmbolismRetrospective StudiesVasoconstrictor AgentsVasoconstrictor AgentsCritical carePrecipitants of decompensationPulmonary EmbolismShock

Identifiers

PMID31408804
PMCPMC7146081
OpenAlexW2964629000

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.