Mechanisms of Leukemia Evolution: Lessons from a Congenital Syndrome.

Yehudit Birger, Ruth Shiloh, Shai Izraeli

Abstract readComment

In one paragraph

Article in Cancer cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

Socioeconomic, Ethnocultural, Substance- and Cannabinoid-Related Epidemiology of Down Syndrome USA 1986-2016: Combined Geotemporospatial and Causal Inference Investigation.International journal of environmental research and public health · 2022
Observational
Clonal Myeloproliferative Disorders in Patients with Down Syndrome-Treatment and Outcome Results from an Institution in Argentina.Cancers · 2022
Article
Cannabinoid and substance relationships of European congenital anomaly patterns: a space-time panel regression and causal inferential study.Environmental epigenetics · 2022
Article
Cannabinoid exposure as a major driver of pediatric acute lymphoid Leukaemia rates across the USA: combined geospatial, multiple imputation and causal inference study.BMC cancer · 2021
Article
A geospatiotemporal and causal inference epidemiological exploration of substance and cannabinoid exposure as drivers of rising US pediatric cancer rates.BMC cancer · 2021
Article
Cannabis and Pregnancy Don't Mix.Missouri medicine
Article

4 · The record

Corrections and comments

Comment on
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.2019

5 · Who and what money

Authors and funding

3 authors.

Yehudit BirgerDivision of Pediatric Hematology and Oncology, Schneider Children's Medical Center of Israel, Petach Tikva 49100, Israel.

Ruth ShilohDivision of Pediatric Hematology and Oncology, Schneider Children's Medical Center of Israel, Petach Tikva 49100, Israel.

Shai IzraeliDivision of Pediatric Hematology and Oncology, Schneider Children's Medical Center of Israel, Petach Tikva 49100, Israel; Sackler Medical School, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel. Electronic address: sizraeli@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies of the mechanisms of acute leukemia transformation from a preleukemic state in humans are hampered by the absence of clinical preleukemia syndromes. In this issue of Cancer Cell, Labuhn et al. provide a functional genomics view on the leukemic evolution from congenital preleukemia in children with Down syndrome.

Indexed as

Down SyndromeLeukemia, Myeloid, AcuteMyelodysplastic SyndromesPreleukemiaCell Transformation, NeoplasticChildHumans

Identifiers

PMID31408616

DOI10.1016/j.ccell.2019.07.004

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.